Novel Otoliths/Bacterial Cellulose Nanocomposites as a Potential Natural Product for Direct Dental Pulp Capping

Costa, Lígia Maria Manzine; Olyveira, Gabriel Molina de; Basmaji, Pierre; Valido, Daisy Pereira; Góis, Plácia Barreto Prata; Júnior, Ricardo Luis Albuquerque Cavalcante; Filho, Lauro Xavier

doi:10.1166/jbt.2012.1031

Cited by 13 publications

(7 citation statements)

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“…Wound dressing/patches Surgical Wounds, flaps and RAS ulcers Chiaoprakobkij et al, [89] Carvalho et al, [119] Biocompatible Physical barrier Allow drug delivery Dental pulp tissue treatment Root canal sealers Jinga et al, [115] Scaffold for regenerative Endodontic treatment Manzine Costa et al, [116] Voeicu et al, [117] Accelerates the hardening processes of cement Reinforce dental cements Mimics extracellular matrix. Induces mineralized barrier and apical closure Dental surgery Surgical suture Wu et al, [118] Improve reinforcement and mechanical properties…”

Section: Periodontal Treatmentmentioning

confidence: 99%

“…Intending to promote a tissue regeneration response by applying the dental pulp capping technique, Manzine Costa and coworkers [ 116 ] developed an otolith/BC nanocomposite (OTL). Subsequently, exposed incisor dental pulps of dogs were divided into two groups: BC/Otolith preparation (OTL) and no protective material in the control group.…”

Section: Bc In Dentistrymentioning

confidence: 99%

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Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Barud¹,

Silva

Borges

et al. 2020

Molecules

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Bacterial cellulose (BC) is a natural polymer that has fascinating attributes, such as biocompatibility, low cost, and ease of processing, being considered a very interesting biomaterial due to its options for moldability and combination. Thus, BC-based compounds (for example, BC/collagen, BC/gelatin, BC/fibroin, BC/chitosan, etc.) have improved properties and/or functionality, allowing for various biomedical applications, such as artificial blood vessels and microvessels, artificial skin, and wounds dressing among others. Despite the wide applicability in biomedicine and tissue engineering, there is a lack of updated scientific reports on applications related to dentistry, since BC has great potential for this. It has been used mainly in the regeneration of periodontal tissue, surgical dressings, intraoral wounds, and also in the regeneration of pulp tissue. This review describes the properties and advantages of some BC studies focused on dental and oral applications, including the design of implants, scaffolds, and wound-dressing materials, as well as carriers for drug delivery in dentistry. Aligned to the current trends and biotechnology evolutions, BC-based nanocomposites offer a great field to be explored and other novel features can be expected in relation to oral and bone tissue repair in the near future.

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Section: Periodontal Treatmentmentioning

confidence: 99%

Section: Bc In Dentistrymentioning

confidence: 99%

Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Barud¹,

Silva

Borges

et al. 2020

Molecules

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“…Shaping of BC materials in the culture medium can be controlled by the type of cultivation that changes chain size, origin of strains which produces different proportions of crystalline phase of BC and the kind of bioreactor. BC hydrogel or BC in dry state is then obtained by methods, such as freeze-drying [9,10]. The structural features of microbial cellulose, its properties and compatibility as a biomaterial for regenerative medicine can be changed by modifying its culture medium [11], or surface modification by physical [12,13], chemical methods [14] and genetic modifications [15], to obtain a biomaterial with less rejection when in contact to the body [16,17].…”

Section: Conclusion: Nanodermmentioning

confidence: 99%

Nanoderm Extracellular Matrix for Reconstructive Surgery Applications

Olyveira¹

2015

Arch Biomed Sci Eng

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Introduction: Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as a support for cell proliferation, its pores allow gas exchange between the organism and the environment. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this scope, Natural ECM is the ideal biological scaffold since it contains all the components of the tissue. The development of mimicking biomaterials and hybrid biomaterial can further advance directed cellular differentiation without specific induction. Methods:The acetic fermentation process was achieved by using glucose as a carbohydrate source. Results of this process are vinegar and a nanobiocellulose biomass. The modifying process is based on the addition of hyaluronic acid and chondroitin sulfate (1% w/w) to the culture medium before the bacteria is inoculated. After, vegetal stem cells were added in the system, which were chosen because has wound healing properties that help new skin formation. (Casearia Sylvestris).Result: Bacterial cellulose (Nanoskin ® ) was successfully modified by changing the fermentation medium as shown by FTIR and TGA, which produced necessary materials for regenerative medicine. Nanoskin Natural extracellular matrix (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. Conclusion: Nanoderm® Natural extracellular matrix (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. Understanding how cells interact with these to assemble their own ECM and how the scaffolds can be used to control delivery of signals in a temporal and spatial manner to guide or maintain cell differentiations need future investigation. But, undoubtedly, natural-origin polymers or nature-inspired materials appear as the natural and desired choice for medical applications.The extracellular matrix (ECM) contains an abundant variety of signals that are received by cell surface receptors and contribute to cell adhesion and cell fate, via regulation of cellular activities such as proliferation, migration and differentiation. As such, regenerative medicine studies often rely on mimicking the natural ECM to promote the formation of new tissue by host cells, and characterization of natural ECM components is vital for the development of new biomimetic approaches [7,8].Bacterial cellulose (Nanoskin ® ) is a natural cellulose produced by bacterial synthesis by biochemical steps and self-assembling of the secreted cellulose fibrils on the medium. Shaping ...

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“…Shaping of BC materials in the culture medium can be controlled by the type of cultivation that changes chain size, origin of strains which produces different proportions of crystalline phase of BC and the kind of bioreactor. BC hydrogel or BC in dry state is then obtained by methods, such as freeze-drying [16] [17]. The structural features of microbial cellulose, its properties and compatibility as a biomaterial for regenerative medicine can be changed by modifying its culture medium [18] or surface modification by physical [19] [20]; chemical methods [21] and genetic modifications [22] to obtain a biomaterial with less rejection when in contact to the body [23] [24].…”

Section: Introductionmentioning

confidence: 99%

Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates

Mualla¹,

Farahat²,

Basmaji³

et al. 2016

JBNB

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Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. In addition, biomedical materials have claimed attention because of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin ®) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Bacterial cellulose fermentation process is modified before the bacteria are inoculated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.

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Novel Otoliths/Bacterial Cellulose Nanocomposites as a Potential Natural Product for Direct Dental Pulp Capping

Cited by 13 publications

References 0 publications

Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Nanoderm Extracellular Matrix for Reconstructive Surgery Applications

Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates

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