Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies

Abstract

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.

Synthesized of Sporopollenin-Immobilized Schiff Bases and Their Vanadium(IV) Sorption Studies

“…O), which indicates the coordination of the ligand to the metal ion. These bands were absent in the spectra of the uncomplexed Schiff bases, thus confirming participation of the O and N atoms in the coordination [20]. The band which appeared at 940-998 cm -1 is assigned to m(V=O).…”

Synthesis of Triphenyltin (IV) and Dibutyltin (IV) Complexes of 1-Aryl-2,5-dithiohydrazodicarbonamides and Their Characterization

“…This particular ligand system and its 3d metal complexes have been shown to possess high antimicrobial activity [1,2]. Anticorrosion properties of these ligands have also been recognized for the corrosion of copper in aqueous chloride solutions [3].…”

Synthesis, characterization, and antibacterial activities of some metal complexes with tripodal Schiff base ligand derived from pyrrole-2-carboxaldehyde

“…Furthermore, it increases the delocalization of π-electrons over the whole chelate ring and enhances the lipophilicity of the complex. This increased lipophilicity enhances the penetration of the complexes into lipid membranes and blocking of metal binding sites on the enzymes of the microorganisms [28][29].…”