Novel Organostannanes with Assorted Drugs: Synthesis, Spectral, and Potentiometric Studies

Puri, J. K.; Kaur, Harminder; Singla, Anita

doi:10.1080/10426507.2012.755971

Cited by 1 publication

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References 23 publications

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“…Also various metal ions play significant role in our biological system as almost one-third of the enzymes in our body involve metal ions in execution of different biological functions. Already extensive research work in the field of potentiometric studies of metal ion interactions with various drugs had been reported [13][14][15][16]. These metal ions serve to bind and orient substrates with respect to the functional groups in the active site so that redox reactions can take place by utilizing the property of variable valency of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

Gupta

2014

IRJPAC

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This present work is a report on the stability constant values of a worthy antibiotic, Ampicillin Trihydrate; D[-]-α-aminobenzyl penicillin; ABP; a semi-synthetic derivative of penicillin with various biologically vital bivalent metal ions (Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Cd 2+ , Sn 2+ , Hg 2+ and Pb 2+ ) recorded in water-ethanol medium 50% V/V at three different temperatures (298K, 308K, 318K)maintaining ionic strength at 0.1M KNO 3 . The effect of temperature was also studied and the corresponding thermodynamic functions ∆Gº, ∆Hº and ∆Sº were calculated and discussed. It is significant to study the stability constants of drugs with these metal ions as they may already be present in human body. The proton-ligand and metal-ligand stability constants were determined by Calvin-Bjerrum pH titration techniques as modified by Irving and Rossitti. This analysis was carried out in order to determine the pk 1 H and log k 1 , values at 298 K, 308 K and 318 K. The metal to ligand mole ratio was maintained at 1:5 in order to fulfil the maximum coordination number of metal ion. The titrations were done in a titration cell with three openings, kept immersed in a thermostated bath.

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Section: Introductionmentioning

confidence: 99%

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

Gupta

2014

IRJPAC

View full text Add to dashboard Cite

show abstract

Novel Organostannanes with Assorted Drugs: Synthesis, Spectral, and Potentiometric Studies

Cited by 1 publication

References 23 publications

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

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