Novel non-toxic high efficient antibacterial azido chitosan derivatives with potential application in food coatings

Kritchenkov, Andreii S.; Egorov, Anton R.; Kurasova, Margarita N.; Волкова, О. В.; Meledina, Tatiana; Lipkan, Nikita A.; Tskhovrebov, Alexander G.; Kurliuk, Aleh V.; Shakola, Tatsiana V.; Dysin, Artem P.; Egorov, Mikle; Savicheva, Elizaveta A.; Santos, Wesley Moreira dos

doi:10.1016/j.foodchem.2019.125247

Cited by 53 publications

(17 citation statements)

References 36 publications

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“…Chemical modification can not only improve the physical and chemical properties of chitosan, it can also retain the unique properties of chitosan and expand the application range of chitosan derivatives. Modified chitosan derivatives have better biocompatibility, bioactivity, anticancer, and antiviral pharmacological effects, including the ability to induce erythrocyte aggregation, promote platelet activation, and activate complement systems other than that of chitosan [8][9][10][11][12][13]. At present, chitosan derivatives have been widely used in both medical materials and biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Introductionmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

View full text Add to dashboard Cite

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“…Among the natural polymers, like cellulose, liver sugar, starch and chitin used in biomedical applications [57][58][59], chitosan has attracted attention because possesses antibacterial, antiviral, and anticancer effects. In addition, relevant chemical and physical modifications of chitosan give derivatives with desirable biodegradability, biocompatibility, bioactivity and non-toxicity properties [60][61][62][63][64]. Chitosan flat structures contribute to biomedical applications, especially for their ability to accelerate wound healing and optimize drug delivery.…”

Section: Biomedicinementioning

confidence: 99%

“…The diffusion of PWA solution into a gel of flat geometry can be controlled by two different mechanisms: (i) the concentration gradient and (ii) the polymer relaxation phenomena [65]. By using a semi-empirical approach derived from the one-dimensional Fick's second law of diffusion applied to chitosan [63], it has been found that at the experimental conditions used in the paper the penetration rate of PWA solution is lower than that of the polymer chains relaxation [9]. At those conditions (0.76 M PWA, Chit 2% wt/v), chitosan is the limiting reagent of the ionotropic gelation reaction and the thickness of the flat chitosan structures grows linearly with the concentration of Chit solution [110].…”

Section: Ionotropic Gelation Reaction Chit Dissolutionmentioning

confidence: 99%

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

et al. 2021

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The capability of some polymers, such as chitosan, to form low cost gels under mild conditions is of great application interest. Ionotropic gelation of chitosan has been used predominantly for the preparation of gel beads for biomedical application. Only in the last few years has the use of this method been extended to the fabrication of chitosan-based flat structures. Herein, after an initial analysis of the major applications of chitosan flat membranes and films and their usual methods of synthesis, the process of ionotropic gelation of chitosan and some recently proposed novel procedures for the synthesis of flat structures are presented.

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“…The azido chitosan derivatives showed excellent antibacterial effect due to the presence of organic azides, which could disrupt the integrity of bacterial cell membrane followed by the leakage of intracellular contents. Meanwhile, the toxicity of azido compounds was diminished (Kritchenkov et al 2019). The CS derivative containing halogeno-1,2,3-triazole groups exhibited antifungal activities against Colletotrichum lagenarium (Pass) Ell.…”

Section: Chitosan Derivatives With Enhanced Antimicrobial Capacitymentioning

confidence: 99%

Applications of chitosan-based biomaterials: a focus on dependent antimicrobial properties

Deng

Wang

Chen

et al. 2020

Mar Life Sci Technol

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Marine-derived chitosan has been widely examined for its use in developing biomedical materials. Not only is it non-toxic, biocompatible, and degradable, it has also shown unique antimicrobial properties. The antimicrobial properties of chitosan are restricted by neutral and physiological conditions because it is insoluble in water and its pKa values is 6.5. One solution to this problem is to graft chemically modified groups onto the backbone of chitosan. The aim of this paper is to review the mode of antimicrobial action of chitosan and chitosan derivatives. Using chitosan alone may not meet the demands of various applications. However, the introduction of additional polymers and antimicrobial agents is commonly used to enhance the antimicrobial potential of chitosan-based biomaterials. Chitosan-based composite biomaterials have been developed that allow diversified formulations to broaden applications, including nanoparticles, hydrogels, films, sponges, fibers, or even microspheres. These along with recent advances on chitosan-based composite biomaterials used for wound healing, food packaging, textile sector, 3D printing and dental materials, were reviewed in detail.

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Novel non-toxic high efficient antibacterial azido chitosan derivatives with potential application in food coatings

Cited by 53 publications

References 36 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

Applications of chitosan-based biomaterials: a focus on dependent antimicrobial properties

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