Novel Non-Invasive Index for Prediction of Responders in Cardiac Resynchronization Therapy Using High-Resolution Magnetocardiography

Abstract

electrocardiogram (ECG) remains of clinical use. 9 Although in large multicenter trials the highest response rate is seen among patients with QRS duration >150 ms and left bundle branch block (LBBB) morphology, 10,11 the sensitivity and specificity of detecting CRT responders based on QRS duration and ECG morphology are not sufficient. An abundance of scars may negate the effect of CRT by C ardiac resynchronization therapy (CRT) has been shown to ameliorate symptoms and cardiac mortality by correcting left ventricular (LV) dyssynchrony in patients with heart failure (HF) and reduced ejection fraction (EF). 1-6 However, CRT is not always effective in approximately one-third of patients. 7 Among various indices predicting CRT responders, 8 only ventricular conduction delay measured using a standard 12-lead