Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing

Ong, Huan Ting; Dilley, Rodney J.

doi:10.1016/j.cytogfr.2018.11.002

Cited by 49 publications

(33 citation statements)

References 101 publications

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“…VEGF is secreted by plateles, keratinocytes, macrophages and fibroblasts and manifests strong paracrine effects on endothelial cells, promotes and supports the process of wound angiogenesis. It is the main growth factor that initiates the angiogenesis process in granulation tissue [21,22]. VEGF growth factors are implicated in the physiological and pathological processes of vasculogenesis, angiogenesis, vascular , and further there is a series of cascade phosphorylates with Akt activation that will lead to cell growth and proliferation.…”

Section: Discussionmentioning

confidence: 99%

Effect of platelet-rich plasma on chronic odontogenic maxillary sinusitis: a pilot study

Miricescu¹,

Totan²,

Rusu³

et al. 2019

EDUJ

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Introduction: Chronic odontogenic maxillary sinusitis (CMOS) is a frequent inflammatory process pertaining to the oro-maxilo-facial pathology. Platelet-rich plasma (PRP) is a natural source of growth factors, which have the potential to stimulate and accelerate the wound healing process. The aim of this study is to observe the effects of the PRP growth factors in patients with CMOS. Methodology: Inflammatory oral mucosa was collected from five patients diagnosed with CMOS, and it was incubated with 2 mL PRP for 7 days. PRP was obtained from venous blood collection from each patient. The control samples were represented by inflammatory sinus mucosa without adding PRP. The following biomarkers were measured using cell lysate: insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1R), glycogen synthase kinase 3 beta (GSK3β), glycogen synthase kinase 3 alfa (GSK3α) performed by Multiplex technology. Results: The results revealed statistically increased levels for all four parameters in patients with CMOS versus controls (p < 0.05). Growth factors from PRP bind to receptors with tyrosine kinase activity, cellular event being correlated with cell proliferation. The radiological control of patients 10 months after PRP administration revealed a decrease in the thickness of the sinus lining up to 3 times. Conclusions: The growth factors released from platelets should be regarded as a positive effect source in the case of patients diagnosed with CMOS. These growth factors should activate the oligopotente stem cells which will finally lead to sinus mucosa regeneration. Future studies are needed to understand the molecular mechanisms that occur at the sinus level.

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Section: Discussionmentioning

confidence: 99%

Effect of platelet-rich plasma on chronic odontogenic maxillary sinusitis: a pilot study

Miricescu¹,

Totan²,

Rusu³

et al. 2019

EDUJ

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Section: Discussionmentioning

confidence: 99%

“…Some lesions can be indistinguishable from other osteolytic jaw lesions on imaging; therefore, histopathology is always necessary for a definitive diagnosis. A prospective study of 82 OKC's reported that 40% were not suspected before surgery [1,22,24]. The surgeons chose not to execute a preoperative incisional biopsy as it can cause inflammation and interfere in the histopathological analysis of the possurgical specimen.…”

Section: Discussionmentioning

confidence: 99%

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2019

EDUJ

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A very positive effect of the globalized information streams is that everybody willing to know what is going on can be very well informed. If you stick to facts rather than believe opinions, an analytic mind can infer from the information available that local actions usually have global effects. The global distribution of pollutants is quite easy to understand, since the weather is quite a global system. I remember two clear examples. When I was a student, I think it was in 1969, I saw a huge tube leaning on the side of the Institute of Physics at the University of Bern. Curious I went to the people working on it and asked them what it was for. They explained to me that the tube was supposed to melt through the ice of Antarctica and that they would take water samples at different depths. Due to the radiocarbon method, they were able to date the samples. Later I learned that with that device they could find soot that was correlated to the first industrial revolution in Europe in the late 1800' s. Another example is the worldwide distribution of nuclear isotopes. I remember that in the 1950' s, when the US was exploding Hydrogen bombs on atolls in the Pacific, it was not allowed to collect rain water for drinking purposes in Switzerland, due to nuclear pollution. The same happened after the 1986 nuclear accident in Chernobyl. 40% of the surface of Europe were contaminated with more than 4 kBq/m 2. Radionuclides traceable to the reactor of Chernobyl were found in all countries of the northern hemisphere. Another good example is business. Since today' s business is interlinked worldwide, every national decision (e.g. tariffs, import/export restrictions etc.) will globally affect the people of other nations. I claim that dentistry is not different and further more I even claim that this is what makes dentistry that interesting. We dentists are dealing with more than teeth. My teacher and mentor Prof. André Schroeder used to say: "To every tooth there is attached a human being!" Isn't this a wonderful way to say that the teeth we are concerned with are part of the very complex machinery of the human body? This is especially true with the ageing population we are faced with today, in combination with successful prevention. This means that the mainstream work of dentists moves from repairing single teeth to treating oral diseases or doing complex reconstructions. Whatever we do, we must consider the individual as a whole that has carried his/her teeth to our office. To understand what has lead to the situation the patients present, we need to know all the general health problems that are associated with the patient, the patient' s habits and wishes, we need to understand the individual oral functions the patient has or has gotten adapted to. Remember that a faulty occlusion may lead to severe muscle pain in the neck and back, which may get chronical, with severe consequences for the patient.

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“…Moreover, several studies have revealed that the implantation time of ASCs is usually too short to have an effective impact [37]. In this context, ASC paracrine activity, through the secretion of a plethora of bioactive factors, was suggested to have the most prominent therapeutic impact in several conditions, including wound healing [38][39][40][41][42]. In this scenario, the study of ASC-conditioned medium (ASC-CM) (also known as ASC-secretome) has opened the way for the development of new cell-free therapies for tissue repair and regeneration [43][44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Secretome of Adipose Tissue-Derived Stem Cells (ASCs) as a Novel Trend in Chronic Non-Healing Wounds: An Overview of Experimental In Vitro and In Vivo Studies and Methodological Variables

Lombardi

Palumbo

Augello

et al. 2019

IJMS

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Wound healing is a complex process with a linear development that involves many actors in a multistep timeline commonly divided into four stages: Hemostasis, inflammation, proliferation, and remodeling. Chronic non-healing wounds fail to progress beyond the inflammatory phase, thus precluding the next steps and, ultimately, wound repair. Many intrinsic or extrinsic factors may contribute to such an occurrence, including patient health conditions, age-related diseases, metabolic deficiencies, advanced age, mechanical pressure, and infections. Great interest is being focused on the adipose tissue-derived stem cell’s (ASC) paracrine activity for its potential therapeutic impact on chronic non-healing wounds. In this review, we summarize the results of in vitro and in vivo experimental studies on the pro-wound healing effects of ASC-secretome and/or extracellular vesicles (EVs). To define an overall picture of the available literature data, experimental conditions and applied methodologies are described as well as the in vitro and in vivo models chosen in the reported studies. Even if a comparative analysis of the results obtained by the different groups is challenging due to the large variability of experimental conditions, the available findings are undoubtedly encouraging and fully support the use of cell-free therapies for the treatment of chronic non-healing wounds.

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Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing

Cited by 49 publications

References 101 publications

Effect of platelet-rich plasma on chronic odontogenic maxillary sinusitis: a pilot study

Effect of platelet-rich plasma on chronic odontogenic maxillary sinusitis: a pilot study

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Secretome of Adipose Tissue-Derived Stem Cells (ASCs) as a Novel Trend in Chronic Non-Healing Wounds: An Overview of Experimental In Vitro and In Vivo Studies and Methodological Variables

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