Novel nitrogen-, phosphorus-containing sterically hindered phenols

Antioxidant Activity and Toxic Effects of Phosphorus-Containing Derivatives of 2,6-Di-tert-Butylphenol in silico and in vitro, in vivo

“…BPs are known to possess a strong capacity for complexing metal-ions such as Ca 2+ , Mg 2+ , Zn 2+ or Fe 2+ , which originates from the potential of both phosphoryl groups coordination to the cation. At the same time, nitrogen-bisphosphonates (N-BPs) can have serious side effects; such species are the most widely used drugs for bone fragility disorders, and the effect may partly be explained by its negative influence on the antioxidant status (Kalyan et al, 2014) At present, antioxidants are created on the basis of alkyl phenol derivatives containing fragments of phosphonates, phosphonic acid esters, which have an antioxidant effect significantly exceeding the analogues used in the industry (Azmukhanova et al, 2016). For example, the calcium salt of bis- [monoethyl(3,5-di-tert-butyl-4-hydroxybenzyl)] phosphonate is used as a stabilising additive in materials which contact with food (Federal Register, 1998).…”