Novel Natural Products from Extremophilic Fungi

Zhang, Xuan; Li, Shoujie; Li, Jinjie; Liang, Zizhen; Changqi, Zhao

doi:10.3390/md16060194

Cited by 59 publications

(39 citation statements)

References 98 publications

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“…It can also be anticipated that improvements in search and discovering pipelines will be promoted in no small measure by focusing heavily on novel culturable micro‐organisms with large genomes, as advocated by Baltz (, ). In this context, future bioprospecting campaigns should not only be focused on micro‐organisms like actinobacteria and fungi that are known to have a prosperity to synthesize antibiotics of therapeutic value (Bérdy ; Newman and Cragg ; Zhang et al ), but also on representatives of under‐explored micro‐organisms with genomes rich in NP‐BGCs, such as cyanobacteria, frankiae, ktedonobacteria and myxobacteria, representatives of all of these taxa are known to be attractive candidates for drug discovery programmes (Dixit and Suseela ; Micallef et al ; Baltz ; Nouioui et al ).…”

Section: Discussionmentioning

confidence: 99%

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Extreme environments: microbiology leading to specialized metabolites

et al. 2019

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Summary The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep‐sea sediments select for micro‐organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro‐organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot‐spots of novel gifted micro‐organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial‐derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.

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Section: Discussionmentioning

confidence: 99%

“…However, Penicillum spp. isolated from an abandoned open-pit containing acid-metal waste in Montana, USA were found to produce interesting, novel bioactive compounds (Zhang et al 2018), whereas algae from acid mine waste have been identified as Chlorella protothecoids var. acidicola and Euglena mutabolis (Johnson 2012).…”

Section: Eukaryotesmentioning

confidence: 99%

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

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“…Breviones (96-99), isolated from the deepest sediment-derived fungus Penicillium sp. (5115 m depth), displayed diverse activities, such as cytotoxicity against HeLa, MCF-7, and A549 cells with IC 50 values of 7.44 to 32.5 µM, respectively, and growth inhibition of HIV-1 with EC 50 value of 14.7 µM against C8166 cells [22,38]. Compounds 100-110 showed antibiotic and inhibition activities against silkworm, while 20-nor-isopimarane diterpenoids, including aspewentins (114-118), asperethers (121-125), asperoloids (119-120), and compounds 130 and 131, showed cytotoxic activities [33,[39][40][41][42][43][44][45].…”

Section: Terpenoid Compoundsmentioning

confidence: 99%

“…compounds 47 and 48 were extracted from other genera and showed antimicrobial activity (MIC between 16 and 64 µg/mL against Escherichia coli, Aeromonas hydrophila, Micrococcus luteus, Staphylococcus aureus, Vibrio anguillarum, Vibrio harveyi, and Vibrio parahaemolyticus) and cytotoxic activity against human cervical carcinoma HeLa, respectively[22][23][24][25][26]. while compounds 47 and 48 were extracted from other genera and showed antimicrobial activity (MIC between 16 and 64 µ g/mL against Escherichia coli, Aeromonas hydrophila, Micrococcus luteus, Staphylococcus aureus, Vibrio anguillarum, Vibrio harveyi, and Vibrio parahaemolyticus) and cytotoxic activity against human cervical carcinoma HeLa, respectively[22][23][24][25][26].…”

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confidence: 99%

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

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Growing microbial resistance to existing drugs and the search for new natural products of pharmaceutical importance have forced researchers to investigate unexplored environments, such as extreme ecosystems. The deep-sea (>1000 m below water surface) has a variety of extreme environments, such as deep-sea sediments, hydrothermal vents, and deep-sea cold region, which are considered to be new arsenals of natural products. Organisms living in the extreme environments of the deep-sea encounter harsh conditions, such as high salinity, extreme pH, absence of sun light, low temperature and oxygen, high hydrostatic pressure, and low availability of growth nutrients. The production of secondary metabolites is one of the strategies these organisms use to survive in such harsh conditions. Fungi growing in such extreme environments produce unique secondary metabolites for defense and communication, some of which also have clinical significance. Despite being the producer of many important bioactive molecules, deep-sea fungi have not been explored thoroughly. Here, we made a brief review of the structure, biological activity, and distribution of secondary metabolites produced by deep-sea fungi in the last five years.

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“…The UV/Vis spectrum showed absorption maxima at 590, 380, 285, and 245 nm. 13 C NMR shifts for compound 11 obtained from overlaid HMBC and 1 H- 13 C HSQC spectra exhibited one methyl signal at δ H 3.69 (CH 3 -23), fourteen aromatic methines grouped by 1 (Table 1). Additionally, fourteen quaternary carbon atoms were identified from 1 H- 13 C HSQC and 1 H- 13 C HMBC as well as 1 H- 13 C HSQC and a 2 Hz long range 1 H- 13 C HMBC spectra, including three carbonyls C-11, C-15, and C-24 (δ C 165.…”

Section: Compound Identificationmentioning

confidence: 99%

Whole Genome Sequence of Dermacoccus abyssi MT1.1 Isolated from the Challenger Deep of the Mariana Trench Reveals Phenazine Biosynthesis Locus and Environmental Adaptation Factors

et al. 2020

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Dermacoccus abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A‒J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here, we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence of the strain contained six secondary metabolite-biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family of phenazine compounds. A pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea.

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Novel Natural Products from Extremophilic Fungi

Cited by 59 publications

References 98 publications

Extreme environments: microbiology leading to specialized metabolites

Extreme environments: microbiology leading to specialized metabolites

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Whole Genome Sequence of Dermacoccus abyssi MT1.1 Isolated from the Challenger Deep of the Mariana Trench Reveals Phenazine Biosynthesis Locus and Environmental Adaptation Factors

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