Novel Nanostructured Pt/CeO₂@Cu₂O Carbon-Based Electrode To Magnify the Electrochemical Detection of the Neurotransmitter Dopamine and Analgesic Paracetamol

Abstract

The fabrication of nanocomposites is essential because a multiphase interface delivers highly sensitive and selective method for the individual and simultaneous electrochemical determination of drugs. Herein, we introduce an electrochemical sensor using Pt/CeO2@Cu2O nanocomposites for simultaneous detection of dopamine (DA) and paracetamol (PA), which were synthesized using a low temperature clean aqueous phase additives-free method with Cu2O as sacrificial template. We investigated the electrochemical behavior of the various modified electrodes by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), in which Pt/CeO2@Cu2O proved to be highly sensitive and selective toward individual and simultaneous detection of DA and PA. Sensitive electrooxidation peak potential at 160 mV and 380 mV from the DPV technique was observed for DA and PA, respectively. Both DA and PA exhibit linear response over the range of 0.5 μM to 100 μM. The stability, reproducibility, and repeatability of the Pt/CeO2@Cu2O were also inspected. The lower detection limits of 0.079 μM and 0.091 μM were recorded for DA and PA, respectively. The practical applicability of the Pt/CeO2@Cu2O–carbon paste electrode (CPE) is toward the simultaneous detection of DA and PA in drugs, as well as in spiked human serum and urine samples.

Transition metal oxide based non‐enzymatic electrochemical sensors: An arising approach for the meticulous detection of neurotransmitter biomarkers

“…Various electrochemical sensors with combined TMOs were also introduced to exhibit the synergistic effects of both TMOs in the electrochemical properties. Certain examples include NiO/ZnO hybrid nanoparticle modified sensors introduced by Reddy et al for the detection of DA and UA, [101] and Pt/CeO 2 @Cu 2 O carbon-based electrode fabricated by Rajamani et al [102] All these electrodes exhibited higher selectivity and sensitivity with decreased detection limits. However, TMOs suffer from certain drawbacks that create hurdles in their practical utilization.…”

Synthesis and characterization of nanoceria for electrochemical sensing applications

“…Pt/CeO 2 @Cu 2 O modied CPE exhibited a linear behavior for DA and paracetamol with the detection limits, e.g., 0.079 mM and 0.091 mM, over the range between 0.5 and 100 mM. 106 The stannum doped CeNPs modied glassy carbon paste electrode was used for the detection of an anti-cancer drug, e.g., dacarbazine. 107 In this work, ruthenium-loaded CeO 2 nanocubes (Ru/ CeO 2 ) with rich oxygen vacancies were used to construct an electrochemical sensing interface.…”

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

“…Nowadays, redox cycling has fascinated many researchers across the globe as signal enhancing mechanism in electrochemical sensing . Sometimes, these surface modification leads to increase in the background current of the sensor system, which ultimately aids in the sensitivity improvement of the electrochemical sensors . In these kind of surface modifications, researchers have used various nanocomposites to enhance the charge transfer across the sensor surface.…”