Novel nanostructured biomaterials: implications for coronary stent thrombosis

Karagkiozaki, V.; Karagiannidis, Panagiotis; Kalfagiannis, N.; Kavatzikidou, Paraskevi; Patsalas, P.; Georgiou, D.; Logothetidis, S.

doi:10.2147/ijn.s34320

Cited by 19 publications

(6 citation statements)

References 44 publications

(47 reference statements)

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“…It plausible that the corona may initiate a systemic inflammatory cascade (or host response), similar to that of tissue rejection, as the proteins interacts with the implanted (and possibly functionalized) ENM coating. These corona or inflammatory cascade could initiate platelet activation, increasing thrombogenic activity, in an already compromised setting 42 . While the possibilities are exciting and novel, the long term implications of the interactions must first be determined.…”

Section: Alternate Routesmentioning

confidence: 99%

Vascular distribution of nanomaterials

Stapleton

Nurkiewicz

2014

WIREs Nanomed Nanobiotechnol

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Once considered primarily occupational, novel nanotechnology innovation and application has led to widespread domestic use and intentional biomedical exposures. With these exciting advances, the breadth and depth of toxicological considerations must also be expanded. The vascular system interacts with every tissue in the body, striving to homeostasis. Engineered nanomaterials (ENM) have been reported to distribute in many different organs and tissues. However, these observations have tended to use approaches requiring tissue homogenization and/or gross organ analyses. These techniques, while effective in establishing presence, preclude an exact determination of where ENM are deposited within a tissue. It is necessary to identify this exact distribution and deposition of ENM throughout the cardiovascular system, with respect to vascular hemodynamics and in vivo/ in vitro ENM modifications taken into account if nanotechnology is to achieve its full potential. Distinct levels of the vasculature will first be described as individual compartments. Then the vasculature will be considered as a whole. These unique compartments and biophysical conditions will be discussed in terms of their propensity to favor ENM deposition. Understanding levels of the vasculature will also be discussed. Ultimately, future studies must verify the mechanisms speculated on and presented herein.

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Section: Alternate Routesmentioning

confidence: 99%

Vascular distribution of nanomaterials

Stapleton

Nurkiewicz

2014

WIREs Nanomed Nanobiotechnol

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“…The surface roughness for different coating surfaces of materials used in stent devices have been experimentally analyzed in some studies 17 . However, theoretical approaches and computational techniques to simulate and analyze materials, extensively used in physics and materials science, have not been applied.…”

Section: Applications Of the Modelsmentioning

confidence: 99%

“… 16 The surface roughness for different coating surfaces of materials used in stent devices have been experimentally analyzed in some studies. 17 However, theoretical approaches and computational techniques to simulate and analyze materials, extensively used in physics and materials science, have not been applied. Due to the reduced costs and potential applications in the development of new materials, thin films simulations can be extensively employed in biomaterials analysis.…”

Section: Applications Of the Modelsmentioning

confidence: 99%

A brief review of mathematical models of thin film growth and surfaces

Forgerini

Marchiori²

2014

Biomatter

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The morphology of thin films has been extensively studied in the last years. The properties of a thin film are closely related to its microstructure, especially to its morphology and surface roughness. Optical reflectivity, conductivity, and porosity are characteristics that depend on the film structure. The knowledge of atomistic details of the thin film growth process is useful for the development of new techniques and the control of thin films and new materials. Models of growth process are very powerful tools that can help researchers to predict and control physical, chemical, and mechanical properties. In this work we briefly summarize the theoretical models that have been used in the studies of thin films growth. By describing the deposition process of atoms/molecules on the surface of the substrate, one can study the evolution of the bulk and the surface roughness of a thin film. If an experimental growth process is appropriately described by a theoretical model (or even a combination of one or more different models), it can also provide indications to control the surface roughness and porosity of the film. Controlling the growth process one can obtain materials with a set of desired properties, namely tribological, porosity, and electrical ones. These characteristics are necessary for example, for hosting a solid lubricant on the surface of the material. We believe that the models presented in this work can be very useful in understanding the mechanisms of control and adherence of electrodeposited films which are commonly used in medical applications such as stent devices. We also believe that the models can be helpful to the understanding surface problems related to the superficial defects in stents.

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“…Nano-biomaterials have become a useful tool for medical applications for several reasons that include compatibility and novel effects due to nanoscale. The possibilities to add biomaterials to the development of nanostructures have opened the door for innovative applications in several fields (Karagkiozaki et al, 2012;Elmowafy et al, 2019). One of the most important is for modern medicine with exceptionally complex problems to solve.…”

Section: Introductionmentioning

confidence: 99%

Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

Melchor-Martínez

Castillo

Macías-Garbett

et al. 2021

Front. Bioeng. Biotechnol.

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Over the past years, biomaterials-based nano cues with multi-functional characteristics have been engineered with high interest. The ease in fine tunability with maintained compliance makes an array of nano-bio materials supreme candidates for the biomedical sector of the modern world. Moreover, the multi-functional dimensions of nano-bio elements also help to maintain or even improve the patients’ life quality most securely by lowering or diminishing the adverse effects of in practice therapeutic modalities. Therefore, engineering highly efficient, reliable, compatible, and recyclable biomaterials-based novel corrective cues with multipurpose applications is essential and a core demand to tackle many human health-related challenges, e.g., the current COVID-19 pandemic. Moreover, robust engineering design and properly exploited nano-bio materials deliver wide-ranging openings for experimentation in the field of interdisciplinary and multidisciplinary scientific research. In this context, herein, it is reviewed the applications and potential on tissue engineering and therapeutics of COVID-19 of several biomaterials. Following a brief introduction is a discussion of the drug delivery routes and mechanisms of biomaterials-based nano cues with suitable examples. The second half of the review focuses on the mainstream applications changing the dynamics of 21st century materials. In the end, current challenges and recommendations are given for a healthy and foreseeable future.

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Novel nanostructured biomaterials: implications for coronary stent thrombosis

Cited by 19 publications

References 44 publications

Vascular distribution of nanomaterials

Vascular distribution of nanomaterials

A brief review of mathematical models of thin film growth and surfaces

Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

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