Novel nano spanlastic carrier system for buccal delivery of lacidipine

DCruz, Cleona Elizabeth Mary; Bhide, Prashant Jivaji; Kumar, Lalit; Shirodkar, Rupesh Kalidas

doi:10.1016/j.jddst.2021.103061

Cited by 7 publications

(1 citation statement)

References 37 publications

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“…The disappearance of the NH2 stretching peak of CXB, which matched with an increase in drug dissolution and the presence of the drug in an amorphous state, refers to a possible incorporation of CXB into the niosomes. This is in agreement with reported findings in the literature [67][68][69] .…”

Section: Ft-ir Analysissupporting

confidence: 94%

Celecoxib Niosomal in-Situ Gel as a Valuable Drug Delivery System for Ocular Inflammation

Ahmed,

Khalil,

Hassanein

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Niosomes are promising nanocarriers for ocular drug administration since they have the potential to enhance the bioavailability and efficacy of different drugs. Meanwhile, topical gels are beneficial for the treatment of ocular inflammation as they improve corneal permeability and increase the contact time with the eye surface. The main purpose of this study was to prepare and evaluate novel niosomal gels for intraocular delivery of celecoxib. Different niosomes were prepared using different surfactants (span 60 and span 40) and cholesterol (30-50 mol %). The optimized formulation made with span 40 and cholesterol (7:3 molar ratio) has a relatively high encapsulation efficiency (~57%) with reasonable particle size for ocular delivery (~348 nm) and showed the highest release of ~65% after 24 hrs compared to other formulations. The optimized niosomal formulation was then used to prepare various formulations of celecoxib in-situ gel and topical hydrogels. The niosomal gels were well tolerated by the eye and showed similar celecoxib corneal permeation. However, the in-situ gel showed a higher anti-inflammatory effect compared to the topical hydrogel and a commercially available diclofenac eye drop. The results shown in this study indicate that celecoxib niosomal in-situ gel is a valuable drug delivery system for ocular inflammation.

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Section: Ft-ir Analysissupporting

confidence: 94%