Novel N-α-amino acid spacer-conjugated phthalimide–triazine derivatives: synthesis, antimicrobial and molecular docking studies

Recent biological applications of heterocyclic hybrids containing s-triazine scaffold

“…In order to develop new potent antibacterial agents, Asadi and coworkers in 2023, synthesized a series ( 61 ) bioconjugates of s -triazine clubbed phthalimide via N -α-amino acids spacer. 70 These conjugates were synthesized in moderate to good yield and characterized through spectroscopic techniques. The biological activities of these compounds against 4 strains of bacteria (2 Gram-positive and 2 Gram-negative) were evaluated.…”

“…In vitro ADME analysis and inhibition against helicase enzyme were also studied and IC 50 = 12.1 mM and CC 50 > 400 mM were obtained (Table 3). Fused ring molecular hybrids of s-triazine and pyrazole (70) are reported as antiviral conjugates. 81 Starting from N-(2,2-dichloro-1cyanoethenyl)-carboxamides, these 5 different substituted molecular hybrids of this series were synthesized in good yield and their biological activity was evaluation against human cytomegalovirus, herpes simplex virus-I, and Varicella-zoster virus.…”

Antifungal, anti-biofilm, and anti-hyphal properties of N-substituted phthalimide derivatives against Candida species

“…Some derivatives of phthalimide, such as the ubiquitous Folpet or the agricultural agent Captan, are proven fungicides with broad-spectrum antimicrobial activity against several fungal species (Kluxen et al, 2022). Other synthetic azole and triazine derivatives of phthalimide have also demonstrated antimicrobial activity against several pathogens (Asadi et al, 2023;Yadav et al, 2023). A study demonstrated that the acridine-isoindoline phthalimide derivatives showed an anti-biofilm effect on Pseudomonas aeruginosa biofilms (Mane et al, 2019).…”