Novel Mycelial Components, Ganoderic Acid Mg, Mh, Mi, Mj and Mk, from the Fungus Ganoderma lucidum

Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography

“…2-10) that were cultivated under good agricultural practice (GAP) by Green Valley Pharmaceutical Co. is 1.4 times higher than other samples (samples no. [11][12][13][14][15][16][17][18][19][20][21][22], which indicated the former might have better quality than the latters. Both G. lucidum and G. sinense are the official two species of Lingzhi recorded in Chinese Pharmacopoeia (2005 edition) and they were considered to have the same therapeutic effects [19].…”

“…Therefore, development of quality control methods for G. lucidum and its related preparations is an essential issue for the effective clinical use of this medicinal herb. However, the previous studies on the quantitative analysis of multiple triterpenoids in G. lucidum are insufficient [13][14][15][16][17][18] due to the difficulty to obtain the standard compounds. Furthermore, the authentication of commercial samples of G. lucidum was generally carried out by applying classical procedure performed by thin layer chromatography (TLC) [19].…”

Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642

“…Structures of the new compounds (1−16) were further confirmed by analysis of 2D NMR spectroscopic data. The known compounds were identified by comparison of the spectroscopic data with those reported in the literature; these are ganorbiformin C (17), 7 astraodoric acid A ( 18), 8 astraodoric acid B ( 19), 8 20, 9 astraodoric acid C ( 21), 8 ganorbiformin E ( 22), 7 ganoderic acid V (23), 7,10 ganorbiformin D (24), 7 25, 11 ganoderic acid Mb (26), 12 ganorbiformin F (27), 7 ganoderic acid Md (28), 12 7-Omethylganoderic acid O (29), 13 ganoderic acid Mi (30), 14 ganorbiformin G (31), 7 32, 15 ganoderic acid TR (33), 16,17 34, 15 35, 18 ganoderic acid R (36), 19 ganoderic acid T (37), 19 38, 20 ganoderic acid S (39), 19 ganoderic acid X (40), 10,21 41, 22 and ganorbiformin A (42). 7 Compound 1 was isolated as a colorless solid, and the molecular formula was determined to be C 32 H 46 O 6 by HRESIMS.…”

Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial‐static culture of Ganoderma lucidum

“…More than 170 GAs had been isolated from Ganoderma species (Baby et al ., 2015). According to the carbon skeletons, there were two types of GAs: type I had only one double bond in the lanostane skeleton, and type II possessed two conjugated double bonds in the tetracyclic rings (Hirotani et al ., 1987; Nishitoba et al ., 1987; Li et al ., 2013). It was reported that several individual GAs had important biological and pharmacological activities, such as antitumor, antimetastasis and anti‐HIV activities (Li et al ., 2013; Bishop et al ., 2015; Gill et al ., 2016; Wu et al ., 2019).…”