Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging

Seo, Sung Baek; Yang, Jaemoon; Hyung, Woochan; Cho, Eun Jin; Lee, Tong Il; Song, Yong Jin; Yoon, Ho Geun; Huh, Yong Min; Haam, Seungjoo

doi:10.1088/0957-4484/18/47/475105

Cited by 33 publications

(19 citation statements)

References 22 publications

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“…The significance of formulating MNPs with various polymer coatings is to minimize macrophage uptake and improve blood circulation time (34–38). There are several commercial dextran or polymer coated MNP formulations with available for diagnostics, but the low in vivo half life and rapid capture of the particles by cells and organs of the RES limits their application to spleen and liver diagnostics (2).…”

Section: Discussionmentioning

confidence: 99%

PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications

et al. 2010

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Purpose-Polyethylene glycol (PEG) functionalized magnetic nanoparticles (MNPs) were tested as a drug carrier system, magnetic resonance imaging (MRI) agent, and ability to conjugate to an antibody.Methods-An iron oxide core coated with oleic acid (OA) and then with OA-PEG forms a water dispersible MNP formulation. Hydrophobic doxorubicin partitions into the OA layer for sustained drug delivery. The T 1 and T 2 MRI contrast properties were determined in vitro and the circulation of the MNPs measured in mouse carotid arteries. An N-hydroxysuccinimide group (NHS) on the OA-PEG-80 was used to conjugate the amine functional group on antibodies for active targeting in the human MCF-7 breast cancer cell line.Results-The optimized formulation had a mean hydrodynamic diameter of 184 nm with an 8 nm iron-oxide core. The MNPs enhance the T 2 MRI contrast, and have a long circulation time in vivo with 30% relative concentration 50 min post-injection. Doxorubicin-loaded MNPs showed sustained drug release and dose-dependent antiproliferative effects in vitro; the drug effect was enhanced with transferrin antibody conjugated MNPs.Conclusion-PEG functionalized MNPs could be developed as a targeted drug delivery system and MRI contrast agent.

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Section: Discussionmentioning

confidence: 99%

PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications

et al. 2010

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“…Combinations of functional nanocrystals (fluorescent quantum dots or MRI‐visible magnetic nanoparticles) and therapeutic agents have been found to be compatible with polymeric nanoparticles ( Table 6 ). 157–160 Desai and co‐workers synthesized biodegradable and surfactant‐free nanoparticles co‐incorporated with hydrophobic drug, Coenzyme Q10, and quantum dots using an arrested precipitation method 161. Hyeon and co‐workers synthesized a similar multifunctional polymer system co‐encapsulated with a hydrophobic therapeutic agent (doxorubicin) and either hydrophobic superparamagnetic nanocrystals or hydrophobic quantum dots, using an oil‐in‐water emulsion and a subsequent solvent evaporation technique 162.…”

Section: Classification Of Hybrid Nanoparticlesmentioning

confidence: 99%

Hybrid Nanoparticles for Detection and Treatment of Cancer

2012

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There is currently considerable effort to incorporate both diagnostic and therapeutic functions into a single nanoscale system for the more effective treatment of cancer. Nanoparticles have great potential to achieve such dual functions, particularly if more than one type of nanostructure can be incorporated in a nanoassembly—referred to in this review as a hybrid nanoparticle. Here we review recent developments in the synthesis and evaluation of such hybrid nanoparticles based on two design strategies (barge vs. tanker), in which liposomal, micellar, porous silica, polymeric, viral, noble metal, and nanotube systems are incorporated either within (barge) or at the surface of (tanker) a nanoparticle. We highlight the design factors that should be considered to obtain effective nanodevices for cancer detection and treatment.

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“…Magnetic NanoParticles (MNPs) have many applications in the biomedical field ranging from biomaterial manipulation and drug delivery in targeted therapy [1][2][3] to such medical applications as treatment through magnetic heating [4]. MNPs used as labels for biosensing have several potentials advantages over other ones.…”

Section: Introductionmentioning

confidence: 99%

Magnetorelaxometry using Improved Giant MagnetoResistance Magnetometer

Denoual¹,

Saez²,

Kauffman³

et al. 2010

Sensors and Actuators A: Physical

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a b s t r a c tMagnetorelaxometry measurements on immobilized superparamagnetic magnetite (Fe 3 O 4 ) nanoparticles in freeze-dried samples using a low-cost Improved Giant MagnetoResistance Magnetometer (IGMRM) are presented. Fits to relaxation phenomenological model based on Moment Superposition Model (MSM) are used to extract the characteristic values. Concentrations of iron down to 3.85 mol are identified in a 150 l volume from experimental measurements. Also, the extracted amplitude characteristic value confidence intervals associated to measurements and detection performances are given.

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Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging

Cited by 33 publications

References 22 publications

PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications

PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications

Hybrid Nanoparticles for Detection and Treatment of Cancer

Magnetorelaxometry using Improved Giant MagnetoResistance Magnetometer

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