Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery

Chen, Daquan; Yu, Hongyun; Mu, Hongjie; Li, Guisheng; Shen, Yan

doi:10.3109/21691401.2013.794358

Cited by 17 publications

(15 citation statements)

References 20 publications

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“…With increase in acidity (decreasing pH), percent drug release from the formulation decreased as shown in Figure 6. Interestingly, no abrupt release of drug from the formulation was observed at any pH, confirming the stability of the drugloaded vesicles (Chen et al 2014). Results show stability of this novel surfactant based formulation at physiological pH of blood.…”

Section: Ee% Determinationsupporting

confidence: 64%

Double-tailed acyl glycoside niosomal nanocarrier for enhanced oral bioavailability of Cefixime

Imran

Shah

Ullah

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Novel, safe, efficient, and cost effective surfactants from renewable resources has attracted attention for enhancing solubility and bioavailability of hydrophobic dugs. We report the synthesis, characterization, and biocompatibility of a novel non-ionic acyl glycoside double-tailed surfactant for niosomal drug delivery system. Structure of the surfactant was confirmed by H NMR and mass spectroscopy. Applications of surfactant in niosomal drug delivery were explored using Cefixime as model. The shape, size, and polydispersity index (PDI) of drug loaded vesicles were investigated with atomic force microscope (AFM) and dynamic light scattering (DLS). Drug entrapping efficiency (EE%) was determined using HPLC. Biocompatibility of the surfactant was evaluated by in vitro cytotoxicity, blood hemolysis, and in vivo acute toxicity. Bioavailability of the surfactant based formulation was investigated in rabbits using HPLC. Vesicles were found to be 159.76 ± 6.54 nm with narrow size distribution and spherical shape. EE% was found to be 71.39 ± 3.52%. Novel surfactant was non-cytotoxicity and hemo-compatible even at 1000 μg/mL concentration and was safe up to 2000 mg/kg body weight. The in vivo bioavailability of niosomal formulation showed elevated plasma concentration and decreased clearance of Cefixime. Current findings reveal that this novel surfactant is biocompatible and could be employed for niosomal drug delivery.

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Section: Ee% Determinationsupporting

confidence: 64%

Double-tailed acyl glycoside niosomal nanocarrier for enhanced oral bioavailability of Cefixime

Imran

Shah

Ullah

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…There are some strategies for these purposes. A few studies reported some drug delivery systems by using natural or synthetic vehicles such as liposome and multicore noisome for enhancement of therapeutic indices of Rh2 15 – 17 . Application of liposome and multicore noisome as drug delivery system is limited by liposomal aggregation and drug leakage.…”

Section: Introductionmentioning

confidence: 99%

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity

Zare‐Zardini

Taheri‐Kafrani

Amiri

et al. 2018

Sci Rep

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In this study, Rh2–treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene (Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2–treated Gr-Lys (Gr-Lys-Rh2) and Rh2–treated Gr-Arg (Gr-Arg-Rh2) were synthesized. MTT assay was used for evaluation of cytotoxicity of samples on ovarian cancer (OVCAR3), breast cancer (MDA-MB), Human melanoma (A375) and human mesenchymal stem cells (MSCs) cell lines. The percentage of apoptotic cells was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The hemolysis and blood coagulation activity of nanostructures were performed. Interestingly, Gr-Arg, Gr-Lys, Gr-Arg-Rh2, and Gr-Lys-Rh2 were more active against cancer cell lines in comparison with their cytotoxic activity against normal cell lines (MSCs) with IC50 values higher than 100 μg/ml. The results of TUNEL assay indicates a significant increase in the rates of TUNEL positive cells by increasing the concentrations of nanomaterials. Results were also shown that aggregation and changes of RBCs morphology were occurred in the presence of GO, GO-Rh2, Gr-Arg, Gr-Lys, Gr-Arg-Rh2, and Gr-Lys-Rh2. Note that all the samples had effect on blood coagulation system, especially on PTT. All nanostrucure act as antitumor drug so that binding of drugs to a nostructures is irresolvable and the whole structure enter to the cell as a drug.

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“…Depending on the types of diseases and lesions, the delivery systems can be modified to target ginsenosides to the specific sites of the body. The targeted delivery of ginsenosides is able to promote their efficient delivery to the site of interest, thereby maximizing the therapeutic efficacy of ginsenosides and also decreasing their possible systemic toxicity [23] , [48] , [50] , [51] . In addition, the administration route of the delivery systems can be varied to avoid the delivery of ginsenosides to unwanted sites and increase the bioavailability [64] , [65] .…”

Section: Factors To Consider For Improving Bioavailability Of Ginsenomentioning

confidence: 99%

“…They have considerably improved the problematic properties of ginsenosides, thereby successfully enhancing their bioavailabilities. The diverse delivery systems have also been administered to the body via different routes to effectively increase the bioavailability of ginsenosides as shown in Table 3 [13] , [35] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] .…”

Section: Introductionmentioning

confidence: 99%

Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability

Kim

Lee

Kim

et al. 2018

Journal of Ginseng Research

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Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.

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Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery

Cited by 17 publications

References 20 publications

Double-tailed acyl glycoside niosomal nanocarrier for enhanced oral bioavailability of Cefixime

Double-tailed acyl glycoside niosomal nanocarrier for enhanced oral bioavailability of Cefixime

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity

Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability

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