Novel Mucoadhesive Gastro Retentive Drug Delivery System of Ranitidine Hydrochloride

Wagh, Priti; Ahirrao, Sapana; Kshirsagar, Sanjay J.

doi:10.5958/2231-5691.2019.00013.3

Cited by 9 publications

(2 citation statements)

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“…The mechanisms of swelling and unfolding enable volume and shape adjustment, which makes them attractive for use in children. This formulation is sometimes referred to as a ‘plug-type’ system because of its ability to inhibit the pyloric sphincter [ 247 , 248 ]. Reported examples include a swellable, asymmetric, triple-layer tablet loaded with tetracycline, metronidazole, and bismuth to treat H pylori .…”

Section: Currents Trends and Gapsmentioning

confidence: 99%

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Rampedi,

Ogunrombi,

Adeleke

2024

Pharmaceutics

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Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they are regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need for effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress in enhancing the effectiveness of paediatric medicines. Generally, these delivery methods target, and address challenges associated with palatability, dosing accuracy, stability, bioavailability, patient compliance, and caregiver convenience, which are important factors that can influence successful treatment outcomes in children. Some of the emerging trends include moving away from creating liquid delivery systems to developing oral solid formulations, with the most explored being orodispersible tablets, multiparticulate dosage forms using film-coating technologies, and chewable drug products. Other ongoing innovations include gastro-retentive, 3D-printed, nipple-shield, milk-based, and nanoparticulate (e.g., lipid-, polymeric-based templates) drug delivery systems, possessing the potential to improve therapeutic effectiveness, age appropriateness, pharmacokinetics, and safety profiles as they relate to the paediatric population. This manuscript therefore highlights the evolving landscape of oral pharmacotherapeutic interventions for leading paediatric infectious diseases, crediting the role of innovative drug delivery technologies. By focusing on the current trends, pointing out gaps, and identifying future possibilities, this review aims to contribute towards ongoing efforts directed at improving paediatric health outcomes associated with the management of these infectious ailments through accessible and efficacious drug treatments.

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Section: Currents Trends and Gapsmentioning

confidence: 99%

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Rampedi,

Ogunrombi,

Adeleke

2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…This system simply implies the placement of a magnetic system inside the formulation variable and another magnetic system that will be placed above the abdomen to retain the formulation in the gastric region to achieve gastric residence time [19].…”

Section: Magnetic Systemmentioning

confidence: 99%