Novel MR-Visible, Biodegradable Microspheres for Transcatheter Arterial Embolization: Experimental Study in a Rabbit Renal Model

Stechele, Matthias; Wittgenstein, Helena; Stolzenburg, Nicola; Schnorr, Jörg; Neumann, Jens; Schmidt, Christian; Günther, Rolf W.; Streitparth, Florian

doi:10.1007/s00270-020-02534-1

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Similarly, the development of visible particles has been an active area of research with several studies reporting computed tomography (CT) and magnetic resonance imaging (MRI) visible particles. 28,38 In theory, particle visibility on follow-up imaging would enable a greater understanding of collateral pathways, embolization dynamics, reduce non-target embolization, as well as aid in the understanding of the relationship between particle distribution and clinical failure. However, it is yet unknown how changing the chemical composition to make particles visible will affect other aspects of their performance.…”

Section: Particlesmentioning

confidence: 99%

Embolic Materials: Understanding the Ocean of Choices

Young

Larson

Torkian

et al. 2022

The Arab Journal of Interventional Radiology

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Embolization is a fundamental procedure that interventional radiologists perform on a daily basis to treat a variety of diseases. The disease processes for which embolization is considered a safe and effective treatment are continuously expanding, as are the embolization materials available for use. To achieve optimal clinical outcomes and minimize complications, it is imperative that the interventional radiologist understands the properties, strengths, and weaknesses of each class of embolic and specific embolic products. This is a continuous process as new materials are always becoming available. This article reviews the different classes of embolic materials, discusses strengths and weaknesses, and reviews areas of innovation.

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Section: Particlesmentioning

confidence: 99%

Embolic Materials: Understanding the Ocean of Choices

Young

Larson

Torkian

et al. 2022

The Arab Journal of Interventional Radiology

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“…Depending on the different sizes of the target vessels, embolic microspheres with different sizes have different distribution characteristics and occlusive endpoints. − For easy injection and to reach the distal ends of the blood vessels, the microspheres are desired to have good elasticity. , Moreover, the surface interactions between the microspheres and microchannels also affect their flow behaviors . Currently, the evaluation of the embolization performances is generally carried out with animal models. − Although animal models can truly reflect the environments in which the embolic microspheres are exposed in tumors, there are some experimental and economic limitations due to the complicated operations. It is very difficult to systematically investigate the spatial distribution and deformation of the embolic microspheres in vivo.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study on Effects of Physico-Chemo-Mechanical Properties of Embolic Microspheres on Embolization Performances

Yang

Deng

et al. 2023

Ind. Eng. Chem. Res.

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In this study, the effects of physico-chemical-mechanical properties of embolic microspheres on embolization performances are systematically investigated for the first time in a self-designed and 3D-printed transparent in vitro embolization chip. With droplet microfluidic devices, monodisperse poly(lactic-co-glycolic acid) (PLGA), chitosan, calcium alginate (Ca-ALG), and poly(vinyl alcohol) (PVA) microspheres with uniform shapes and controllable diameters are successfully fabricated. The embolization performances of microspheres with different physico-chemical-mechanical properties, including the elastic properties, surface adhesion properties, and sizes, are evaluated by observing the embolization positions of microspheres in the microchannels inside the chip and measuring the embolization-induced decreases of trans-channel water fluxes of the chip. The results show that for the microspheres with large Young’s moduli and low surface adhesion properties, the microchannel diameters that can be embolized by microspheres are almost the same as the corresponding microsphere diameters; however, when the microspheres have very low Young’s moduli, they can deform in the microchannels and pass through microchannels with diameters much smaller than the microsphere diameters. Generally, embolic microspheres with good elastic property, low surface adhesion property, and suitable size can achieve desired embolization performances. This work provides a new platform for controllable fabrication and performance characterization of future materials for embolization, and the results provide valuable guidance for designing efficient embolic materials for the transcatheter arterial embolization therapy.

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“…In this issue of CVIR, Stechele et al [2] have evaluated new resorbable and MRI visible particles in a rabbit kidney model. The particles were composed of polydioxanone impregnated with super-paramagnetic iron oxide (SPIO).…”

mentioning

confidence: 99%

Visibility and Resorption: Are These Features Important?

Golzarian

2020

Cardiovasc Intervent Radiol

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Novel MR-Visible, Biodegradable Microspheres for Transcatheter Arterial Embolization: Experimental Study in a Rabbit Renal Model

Cited by 4 publications

References 42 publications

Embolic Materials: Understanding the Ocean of Choices

Embolic Materials: Understanding the Ocean of Choices

In Vitro Study on Effects of Physico-Chemo-Mechanical Properties of Embolic Microspheres on Embolization Performances

Visibility and Resorption: Are These Features Important?

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