“…Because Ser5 is heavily phosphorylated in multiple immune cell lineages after stimulation ( Wang et al, 2010 ; Hagi et al, 2006 ; Freeley et al, 2012 ; De Clercq et al, 2013 ), most work has focused on Ser5 phosphorylation of LPL in regulating cell activation and motility. We reported recently that Ser5 phosphorylation is required for efficient splenic clearance of blood-stream infection with Streptococcus pneumoniae , myeloid cell phagocytosis, and generation of splenic marginal-zone macrophages ( Anaya et al, 2021 ). However, we have not noted defects in macrophage podosome formation or NLRP3 inflammasome activation in macrophages from S5A mice ( Anaya et al, 2021 ).…”