Novel molecular classification of colorectal cancer and correlation with survival

Mangi, Fayaz Hussian; Shaikh, Tanweer Ahmed; Soria, Daniele; Waryah, Ali Muhammad; Ujjan, Ikram Din; Qureshi, Jawaid Naeem; Syed, Binafsha Manzoor

doi:10.1016/j.sjbs.2022.03.014

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Discussion of Molecular typing alone is less comprehensive, and individualized assessment of disease conditions inevitably takes into account demographic characteristics, clinicopathological characteristics, molecular markers, lifestyle and nutritional factors, and chemical agents. Subsequent classification reports, such as the Jass Classification of CRC (130), CCS Classification (131), Ogino Classification System (132) and Mangi Classification of CRC (133), mostly used CIMP, MSI, CIN, RAS and other markers as prototypes to explore the future direction of neoadjuvant therapy and targeted therapy in the clinical environment.…”

Section: Rasmentioning

confidence: 99%

Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)

et al. 2023

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Colorectal cancer (CRC) is a malignant tumor and a major cause of morbidity and mortality globally. The classic Tumor-Node-Metastasis staging system, which currently underlies the diagnosis and treatment of CRC, is primarily a 'one drug fits all' model for patients exhibiting the same pathological features. However, a high degree of variability has been established in the long-term survival outcomes of patients with CRC with similar pathological types and stages, which can be partially attributed to tumor-specific molecular biology to some extent. Molecular classification of CRC can further assist with understanding the biological behavior of tumor genesis, development and prognosis, and assist clinicians in improving or customizing the treatment strategy of CRC. In the present study, clinical studies carried out to date are reviewed, and their clinical value is discussed. A multilevel overview of the major molecular types of CRC is provided, in the hope that investigators are encouraged to combine multiple omics studies for interrogating cancer. Contents 1. Introduction 2. Genome-based molecular typing of CRC 3. Transcriptome-based molecular typing of CRC 4. Proteome-based molecular typing of CRC 5. Conclusions

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Section: Rasmentioning

confidence: 99%

Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)

et al. 2023

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CDX2 protein distribution in the gastric mucosa in chronic gastritis by a semi-quantitative index and its reproducibility

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Мозговой

Shimanskaya

et al. 2023

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Introduction The Cdx2 gene provides an intestinal differentiation of epithelial cells and plays an oncosupressive role. An indirect method of the Cdx2 gene expression assessment is the immunohistochemical study of its product, the CDX2 protein. Therefore, the common approach to the immunohistochemical study of the CDX2 protein hasn’t been developed yet. A semi-quantitative CDX2 index based on the percentage of CDX2-positive cells in the tissue specimen, the staining intensity and an expression pattern has been proposed.The purpose of the study was to assess the reproducibility of the semi-quantitative CDX2 index calculation in chronic atrophic gastritis stages I-IV.Materials and methods 20 chronic atrophic gastritis cases (5 cases for each stage of the gastritis according to the Operative link for gastritis assessment system) were taken according to the Maastricht V protocol and examined by the immunohistochemical method (CDX2, clone EPR2764Y, ready to use). The reproducibility of the CDX2 semi-quantitative index was assessed by five pathologists. An agreement between observed raters was measured by the kappa statistics.Results The Cohen’s κ value is 0,8 for unweighted κ and 0,97 for weighted κ (extremely high level of agreement) for the semi-quantitative CDX2 index calculation.Discussion The least reproducible parameter used for the semi-quantitative CDX2 index calculation the percentage of CDX2-positive cells because of the subjective assessment. The Cohen’s weighted κ value was higher compared to the unweighted κ because of the close yet not similar CDX2 semi-quantitative index values calculated by pathologists.Conclusion The semi-quantitative CDX2 index can be used to rank CDX2 expression and has a high level of reproducibility.

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Novel molecular classification of colorectal cancer and correlation with survival

Cited by 2 publications

References 34 publications

Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)

Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)

CDX2 protein distribution in the gastric mucosa in chronic gastritis by a semi-quantitative index and its reproducibility

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