Novel microbicide graphene oxide nanocomposite hydrogel against herpes simplex virus

Salama, Ahmed M.; Metry, Mena E.; Abdelhamid, Ahmed E.; Elbisi, M.K.; Yasin, Ghulam; Lu, Jun

doi:10.1016/j.mtchem.2023.101676

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Even though the antiviral efficacy of 1 wt % HOF-101@PVDF MMMs was diminished at 273 K after 20 min for both viruses, they still manifested an antiviral effect exceeding 99% and 95% for VSV and HSV-1, respectively (Figure c). The antiviral performance of HOF-101@PVDF MMMs was comparable to those of many superior antiviral materials, such as graphene oxide composites, , silicon nitride, and precious metal nanoparticles . To evaluate the long-acting antiviral activity of HOF-101@PVDF MMMs, we assessed their repetitive antiviral performance.…”

Section: Resultsmentioning

confidence: 99%

Hydrogen-Bonded Organic Frameworks Based Mixed-Matrix Membranes with Low Temperature Antiviral Activity

Wang,

Jia,

Cai

et al. 2024

ACS Appl. Polym. Mater.

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Hydrogen-bonded organic frameworks (HOFs) are a type of porous molecular crystal consisting of multiple rigid large π-conjugated structures. They hold great potential as photosensitive antiviral materials due to their solution processability. Moreover, HOFs can easily bind to polymeric matrices, making them a flexible and green option for low-temperature antiviral materials. In this study, we fabricated a series of HOF@polymer mixed-matrix membranes (MMMs) by a solution casting technique for low temperature antiviral applications. The incorporation of HOF-101 crystals into poly vinylidene difluoride (PVDF) membranes can enhance their mechanical strength by at least 20%. The unique one-dimensional pore channels of HOF-101 enable the MMMs to have increased exposure to oxygen, providing the potential for enhanced generation of singlet oxygen ( 1 O 2 ). The 1 O 2 generated by 1 wt % HOF-101@PVDF MMMs at 263 K was observed to be more than 40% higher compared to that at 298 K. The excellent 1 O 2 generation efficiency allowed the MMMs to maintain their virucidal efficacy by more than 99% and 95% against vesicular stomatitis virus and herpes simplex virus type 1, respectively, at low temperatures.

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