Novel Method of Stump Closure for Distal Pancreatectomy with a 75% Reduction in Pancreatic Fistula Rate

Blansfield, Joseph; Rapp, Megan; Chokshi, Ravi J.; Woll, Nicole; Hunsinger, Marie; Sheldon, David G.; Shabahang, Mohsen

doi:10.1007/s11605-011-1794-1

Cited by 44 publications

(40 citation statements)

References 11 publications

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“…In this context, radiofrequency (RF) energy has been used both experimentally and clinically to manage the pancreatic remnant after DP due to its ability to seal the main and secondary pancreatic ducts [4,5].…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency-induced heating versus mechanical stapler for pancreatic stump closure:in vivocomparative study

Burdı́o

Dorcaratto

Hernández

et al. 2016

International Journal of Hyperthermia

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Section: Introductionmentioning

confidence: 99%

Radiofrequency-induced heating versus mechanical stapler for pancreatic stump closure:in vivocomparative study

Burdı́o

Dorcaratto

Hernández

et al. 2016

International Journal of Hyperthermia

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“…Radiofrequency (RF) energy has been used both experimentally and clinically to manage the pancreatic remnant after distal pancreatectomies to seal the main and secondary pancreatic ducts [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Long-term evolution of acinar-to-ductal metaplasia and β-cell mass after radiofrequency-assisted transection of the pancreas in a controlled large animal model

Quesada¹,

Andaluz

Cáceres

et al. 2016

Pancreatology

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ABSTRACT:Background: Pancreatic duct ligation (PDL) has been used as a model of chronic pancreatitis and as a model to increase β-cell mass. However, studies in mice have demonstrated acinar regeneration after PDL, questioning the long-term validity of the model. We aim to elucidate whether RF-assisted transection (RFAT) of the main pancreatic duct is a reliable PDL model, both in short (ST, 1-month) and long-term (LT, 6-months) follow-ups. Methods: Eleven pigs were subjected to RFAT. Biochemical (serum/peripancreatic amylase and glucose) and histological changes (including a semiautomatic morphometric study of over 1000 images/pancreas and IHC analysis) were evaluated after ST or LT follow-up and also in fresh pancreas specimens that were used as controls for 1 (n=4) and 6 months (n=6). Results: The distal pancreas in the ST was characterized by areas of acinar-to-ductal metaplasia (56%) which were significantly reduced at LT (21%) by fibrotic replacement and adipose tissue. The endocrine mass showed a normal increase. Conclusion: RFAT in the pig seems to be an appropriate PDL model without restoration of pancreatic drainage or reduction of endocrine mass.

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“…Preventing PF is crucial for the safety of DP. Although several techniques have been advocated to close the stump of the remnant pancreas, such as hand-sewn closure, stapler closure, ultrasonic dissection, seromuscular patches, and pancreaticoenteric anastomosis, it remains unclear which of these techniques is optimal [6][7][8][9][10]. Currently, stapler and hand-sewn closures are widely performed as standard techniques [11,12].…”

Section: Introductionmentioning

confidence: 99%

Closure method for thick pancreas stump after distal pancreatectomy: soft coagulation and polyglycolic acid felt with fibrin glue

Akita

Takahashi

Gotoh

et al. 2015

Langenbecks Arch Surg

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Novel Method of Stump Closure for Distal Pancreatectomy with a 75% Reduction in Pancreatic Fistula Rate

Abstract: The use of radiofrequency dissector in distal pancreatectomy is effective with low rates of fistula formation. Radiofrequency closure should be studied further in prospective trials.

Cited by 44 publications

References 11 publications

Radiofrequency-induced heating versus mechanical stapler for pancreatic stump closure:in vivocomparative study

Radiofrequency-induced heating versus mechanical stapler for pancreatic stump closure:in vivocomparative study

Long-term evolution of acinar-to-ductal metaplasia and β-cell mass after radiofrequency-assisted transection of the pancreas in a controlled large animal model

Closure method for thick pancreas stump after distal pancreatectomy: soft coagulation and polyglycolic acid felt with fibrin glue

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