Novel method of noninvasive ventilation supported therapeutic lavage in pulmonary alveolar proteinosis proves to relieve dyspnea, normalize pulmonary function test results and recover exercise capacity: a short communication
Abstract:Whole lung lavage (WLL) under general anesthesia with a double-lumen endobronchial intubation has remained standard treatment option for pulmonary alveolar proteinosis (PAP) for over fifty years now. To the best of our knowledge, this is the first description of noninvasive ventilation (NIV) as an innovative alternative, which enables safe and effective treatment. NIV support enabled cost-effective lavage of the most affected segments and resulted in restoration and long-term maintenance of exercise capacity a… Show more
“…Therefore, it is recommended to collect specimen directly from the lower respiratory tract if possible. In particular in severe, intubated patients, the targeted BAL of the most involved lobe should be considered alongside the potential risk of using bronchofiberoscopy in such difficult setting [6]. The patient did not expectorate and standard BAL was not feasible due to the severity of patient' s condition.…”
“…Therefore, it is recommended to collect specimen directly from the lower respiratory tract if possible. In particular in severe, intubated patients, the targeted BAL of the most involved lobe should be considered alongside the potential risk of using bronchofiberoscopy in such difficult setting [6]. The patient did not expectorate and standard BAL was not feasible due to the severity of patient' s condition.…”
“…3 Recently, it was shown that lung lavage with flexible bronchoscopy (FB) is facilitated by NIV. 4 A potential alternative of NIV to treat respiratory failure is the nasal delivery of high-flow oxygen which refers to the entry of air and oxygen through a humidifier in a high-flow circuit. It has been shown that a flow of air of 40 L/min is well tolerated in adults and that the gas flowing during inspiration is maintained at the appropriate temperature and humidity.…”
Flexible video bronchoscopy is a procedure that plays an important role in diagnosing various types of pulmonary lesions and abnormalities. Case 1 is a 68-year-old male patient with a lesion in the right lung apex of approximately 4 mm × 28 mm with atelectasis bands due to a crash injury. High-flow system with 35 L/min and fraction of inspired oxygen (FiO2) 0.45 and temperature of 34 °C was installed prior to the video bronchoscopy. SpO2 was maintained at 98%–100%. The total dose of sedative was 50 mg of propofol. In Case 2, a 64-year-old male patient with bronchiectasis, cystic lesions and pulmonary fibrosis of the left lung field was placed on a high-flow system with 45 L/min and 0.35 FiO2 at a temperature of 34 °C. SpO2 was maintained at 100%. The total duration of the procedure was 25 min; SpO2 of 100% was sustained with oxygenation during maintenance time with the flexible bronchoscope within the airway. The total dose of propofol to reach the degree of desired sedation was 0.5–1 mg/kg. Both patients presented hypotension. For the patient of case 1, a vasopressor (norepinephrine at doses of 0.04 µg/kg/min) was given, and for the patient of case 2, only saline volume expansion was used. The video bronchoscopy with propofol sedation and high-flow nasal cannula allows adequate oxygenation during procedure in the intensive care unit.
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