Novel Method of Lactic Acid Production by Electrodialysis Fermentation

Hongo, Motoyoshi; Nomura, Yasuya; Iwahara, M.

doi:10.1128/aem.52.2.314-319.1986

Cited by 170 publications

(36 citation statements)

References 18 publications

(21 reference statements)

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“…as described by Hongo et al (1986). The medium of fermentation culture for immobilized cells is as follows: 50 g/L glucose, 20 g/L yeast extract, 8.0 g/L polypeptone, 2.0 g/L K2HPO4, 0.5 g/L MgS04.7Hz0, 0.1 g/L NaC1, and 2.5 g/L CaClz.2Hz0.…”

Section: Modelmentioning

confidence: 99%

Mathematical Model for Analysis of Mass Transfer for Immobilized Cells in Lactic Acid Fermentation

Wang

Seki

Furusaki

1995

Biotechnology Progress

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A new mathematical model is proposed to analyze the mass transfer behavior in lactic acid fermentation using immobilized cells entrapped in calcium alginate. The model is comprised of material balance equations for glucose, free lactic acid, and several ions. The dissociation rate of lactic acid (rdiss) is involved in the proposed equations. To solve the equations numerically, a modified calculating method is proposed. Through model analysis, the possible mass transfer behavior in the gel bead was discussed. The model is validated by comparisons with the experimental results obtained from batch and continuous fermentation. The simulations using the model were made to investigate the mass transfer limitation in the gel beads. The results showed that the cell density gradient was formed in the gel beads and it was caused by the accumulation of the inhibitory product (free lactic acid), not by substrate starvation. Moreover, unusual mass transfer behavior of lactate ion in the immobilization support was pointed out.

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Section: Modelmentioning

confidence: 99%

Mathematical Model for Analysis of Mass Transfer for Immobilized Cells in Lactic Acid Fermentation

Wang

Seki

Furusaki

1995

Biotechnology Progress

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“…Many studies have been implemented with direct flow of fermentation broth from fermenter to ED stack without intermediate steps, and the performance of fermentations increased to a certain degree. 29,75,76 The common factor in these studies is that a continuous operation model was adapted for the ED. Processing crude broth directly by ED is a simple and convenient combination with a fermenter, but the microbial cells and proteins can adhere to the membranes and this kind operation will accelerate membrane fouling.…”

Section: In Situ Integration Of Ed and Fermentationmentioning

confidence: 99%

“…As concluded by Hongo et al, this phenomenon will be the limiting factor in this electrodialysis fermentation. 29 Many other studies used pretreatment units for processing the broth between the fermenter and the ED equipment, and the three operating units worked together. Ultrafiltration was often employed during recovering and transporting bioproducts with recirculating of biomass back into the fermenter, e.g.…”

Section: In Situ Integration Of Ed and Fermentationmentioning

confidence: 99%

Noteworthy issues for producing and transforming bioproducts by electrodalysis

Wang

Zhang

et al. 2014

J of Chemical Tech & Biotech

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Bioproducts have been used as bulk chemicals for processing and producing materials, chemicals and energy. The growing environmental concerns and shrinking reserves of fossil fuel have directed the attention to the production of bioproducts from renewable resources. Integrating sustainability considerations into bioproducts development make biotechnology a dominating technology platform. As bioproducts transformation and purification often contribute most to the final cost, improvements in separation techniques are essential to achieve competitive and efficient bioprocesses. One major breakthrough in transforming bioproducts is thus expected to come from novel separation techniques. Among them, electrodialysis (ED) with ion exchange membranes (IEM) has deserved special attention due to its diversity, sophisticated functions and technological compatibility. It is considered a very competitive technology when it comes to the transformation and separation of bioproducts. This review will focus on some noteworthy issues about ED technologies in producing and transforming bioproducts. © 2014 Society of Chemical Industry

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“…Electrodialysis (ED) is a technology to separate and enrich target substances by transferring the ionic forms through a selectively transmissible ion exchange membrane under an electrochemically induced oxidation/reduction reaction [11]. The separation of fermentation metabolites by electrodialysis was proposed to prevent the inhibition of lactic acid [13]. Im et al reported that BES-based C1 gas conversion produced up to 8.4 g/L of acetate, which is an industrially useful intermediate chemical and a source for further biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Separation of Acetate Produced from C1 Gas Fermentation Using an Electrodialysis-Based Bioelectrochemical System

et al. 2018

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The conversion of C1 gas feedstock, such as carbon monoxide (CO), to useful platform chemicals has attracted considerable interest in industrial biotechnology. One conversion method is electrode-based electron transfer to microorganisms using bioelectrochemical systems (BESs). In this BES system, acetate is the predominant component of various volatile fatty acids (VFAs). To appropriately separate and concentrate the acetate produced, a BES-type electrodialysis cell with an anion exchange membrane was constructed and evaluated under various operational conditions, such as applied external current, acetate concentration, and pH. A high acetate flux of 23.9 mmol/m2∙h was observed under a −15 mA current in an electrodialysis-based bioelectrochemical system. In addition, the initial acetate concentration affected the separation efficiency and transportation rate. The maximum flux appeared at 48.6 mmol/m2∙h when the acetate concentration was 100 mM, whereas the effects of the initial pH of the anolyte were negligible. The acetate flux was 14.9 mmol/m2∙h when actual fermentation broth from BES-based CO fermentation was used as a catholyte. A comparison of the synthetic broth with the actual fermentation broth suggests that unknown substances and metabolites produced from the previous bioconversion process interfere with electrodialysis. These results provide information on the optimal conditions for the separation of VFAs produced by C1 gas fermentation through electrodialysis and a combination of a BES and electrodialysis.

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Novel Method of Lactic Acid Production by Electrodialysis Fermentation

Cited by 170 publications

References 18 publications

Mathematical Model for Analysis of Mass Transfer for Immobilized Cells in Lactic Acid Fermentation

Mathematical Model for Analysis of Mass Transfer for Immobilized Cells in Lactic Acid Fermentation

Noteworthy issues for producing and transforming bioproducts by electrodalysis

Separation of Acetate Produced from C1 Gas Fermentation Using an Electrodialysis-Based Bioelectrochemical System

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