Current geopolitical tensions together with the global pandemic have provided important lessons for the need to independently re-evaluate our healthcare needs, guide and promote patient self-awareness and patient-centred care and to consider how cross-border medical information needs have become connected. The pandemic and war have also led to various humanitarian and healthcare crises for which there’s a need to re-evaluate and develop technologies to better manage Personal Health Records (PHRs) for displaced refugees with chronic diseases crossing borders. The recent trend of mobile platform-based, and electronic health record for e-health technologies enabled cloud-based PHR management as a paradigm for patient centred care. However, these platforms are yet to gain use-ubiquity globally. Here we performed a Prospective Register of Systematic Reviews (PROSPERO) registered and Preferred Reporting Items Systematic and Meta-Analyses (PRISMA)-guided systematic review and meta-analysis of the Personal Health Record looking at outcomes such as data security, efficiency, privacy, cost-based measures to generate a benchmark for future studies in this area. A meta-analysis of twelve axes for a future Global Patient co-Owned Cloud (GPOC) highlight the potential in health economics, performance, cryptography and speed of the basic techniques that are currently available, that would facilitate the construction of a GPOC. Whilst the field is early in its development, we highlight barriers, limitations and solutions through a proposed global consensus to ensure appropriate value delivery, safety and ethical governance for global digital personal health record adoption that can fundamentally beneficially transform the future of healthcare.