Novel method for production and purification of untagged pneumococcal surface protein A from clade 1
Tasson da Costa Rodrigues,
Patricia Zorzete,
Eliane Namie Miyaji
et al.
Abstract:Streptococcus pneumoniae can cause diseases with high mortality and morbidity. The licensed vaccines are based on capsular polysaccharides and induce antibodies with low cross reactivity, leading to restricted coverage of serotypes. For surpassing this limitation, new pneumococcal vaccines are needed for induction of broader protection. One important candidate is the pneumococcal surface protein A (PspA), which can be classified in 6 clades and 3 families. We have reported an efficient process for production a… Show more
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