Novel metal complexes, their spectrophotometric and QSAR studies

Aslan, Güzin; Önal, Zülbiye

doi:10.1007/s00044-013-0818-7

Cited by 8 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The procedures of antibacterial activity assay were evaluated according to the literature . The synthesized compounds were tested against colon carcinoma cell line (HCT‐116) .…”

Section: Methodsmentioning

confidence: 99%

“…The procedures of antibacterial activity assay were evaluated according to the literature. [20] The synthesized compounds were tested against colon carcinoma cell line (HCT-116). [21] Antitumor viability assay was performed by the described method by Saintigny and Monnat Jr. [22] 3 | RESULTS AND DISCUSSION…”

Section: Biological Activity and In Vitro Cytotoxicity Assaysmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and cytotoxic evaluation of some substituted pyrazole zirconium (IV) complexes and their biological assay

El‐Shwiniy

Shehab

Mohamed

et al. 2018

Applied Organom Chemis

View full text Add to dashboard Cite

Pyrazole and their derivatives are found to have intense biological efficiency. In the present work some substituted pyrazole derivatives were synthesized and used as ligands (4‐[2‐vinylthiophene]‐3‐methyl pyrozolin‐5(4H) ‐ one (L1), 4‐[4‐chloro benzylidine]‐3‐methyl pyrozolin‐5(4H) ‐ one (L2) and 4‐[4‐dimethylnitro benzylidine]‐3‐methylpyrozolin‐5(4H) ‐ one (L3)) to prepare the zirconium (IV) complexes. The synthesized ligands and their complexes were obtained as colored powdered materials and were characterized using magnetic measurements, melting point, molar conductance, infrared, electronic, 1HNMR, mass spectra and thermogravimetric analyses. All of the tested compounds showed good microbial activity against pathogenic microorganisms. The tested compounds exhibited considerable antitumor activity and cytotoxic specificity towards human colon carcinoma cell line (HCT‐116).

show abstract

“…The procedures of antibacterial activity assay were evaluated according to the literature . The synthesized compounds were tested against colon carcinoma cell line (HCT‐116) .…”

Section: Methodsmentioning

confidence: 99%

Section: Biological Activity and In Vitro Cytotoxicity Assaysmentioning

confidence: 99%

Synthesis and cytotoxic evaluation of some substituted pyrazole zirconium (IV) complexes and their biological assay

El‐Shwiniy

Shehab

Mohamed

et al. 2018

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Design, Synthesis, Cytotoxic Activity, and In Silico Studies of New Schiff Bases Including Pyrimidine Core

Karatas¹,

Ridler²,

Türkmenoğlu³

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

In here, two new Schiff base molecules (3 and 4) were synthesized from the condensation reaction of 1-amino-5benzoyl-4-phenylpyrimidine-2(1H)-one (1) and 1-amino-5-(4methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one (2) with 4-bromobenzaldehyde. These molecules were completely characterized by IR, NMR, and HR-MS. Moreover, molecule 4 was determined by single crystal x-ray diffraction (SC-XRD) patterns. The crystallographic analysis revealed that molecule 4 crystallizes in the monoclinic system, space group P2 1 /c. The molecules were screened in colon, lung and liver cell lines. The results showed that molecule 4 had cytotoxic activity in all screened cancer cell lines. Molecular docking studies of molecules 3 and 4, which were synthesized experimentally and whose cytotoxic activities were examined, were carried out with in silico approaches. Binding parameter values and active binding sites were determined by interacting the compounds with EGFR (PDB ID : 1M17) and VEGFR-2 (PDB ID : 4ASD) crystal structures, respectively, in molecular docking. In addition, the theoretical pharmacokinetic properties of compounds 3 and 4 were evaluated using ADME analysis.

show abstract

New sulfonyl hydrazones and their Pd(II) complexes: synthesis and cytotoxic activities in the MDA-MB-231 cell line

Aslan

2021

Chem. Pap.

View full text Add to dashboard Cite

Novel metal complexes, their spectrophotometric and QSAR studies

Cited by 8 publications

References 21 publications

Synthesis and cytotoxic evaluation of some substituted pyrazole zirconium (IV) complexes and their biological assay

Synthesis and cytotoxic evaluation of some substituted pyrazole zirconium (IV) complexes and their biological assay

Design, Synthesis, Cytotoxic Activity, and In Silico Studies of New Schiff Bases Including Pyrimidine Core

New sulfonyl hydrazones and their Pd(II) complexes: synthesis and cytotoxic activities in the MDA-MB-231 cell line

Contact Info

Product

Resources

About