Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study

Brahimaj, Adela; Rivadeneira, Fernando; Muka, Taulant; Sijbrands, Eric; Franco, Oscar H.; Dehghan, Abbas; Kavousi, Maryam

doi:10.1007/s00125-019-4921-2

Cited by 53 publications

(32 citation statements)

References 53 publications

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“…We identified novel epigenetic correlates of circulating TNF-α and linked these loci to CHD risk [84]. We reported serum apoCIII levels, apoCIII-to-apoA1 ratio, visceral adiposity index, lipid accumulation product, the product of triacylglycerol and glucose to be associated with incident T2D, in particular in women [85,86]. Mendelian randomization (MR) did not support the causal role of serum gamma-glutamyl transferase, as a marker of oxidative stress, on T2D risk [87].…”

Section: Main Results In the Last 3 Yearsmentioning

confidence: 97%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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Section: Main Results In the Last 3 Yearsmentioning

confidence: 97%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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“…When compared to clamp TyG index would even perform better than HOMA-IR (21). TyG index was also reported to be a marker of metabolic disorders (7,12,22) and a good predictor of incident type 2 diabetes (23)(24)(25). In our population of patients with type 2 diabetes TyG index was associated strongly with higher HOMA-IR and more marked metabolic disorders including higher BMI, waist circumference, total cholesterol, triglycerides, LDL-cholesterol, non-HDL cholesterol, plasma glucose and HbA1c levels, lower HDLcholesterol levels and also less physical activity.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

Thai

Tien

Minh³

et al. 2020

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Background Triglyceride Glucose index (TyG) was associated with an increased risk of cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country, the burden of cardiovascular disease is growing in parallel to the epidemiologic transition. The aim was in patients with type 2 diabetes and no history or symptom of cardiovascular disease, to assess the prevalence of coronary stenoses (CS) and investigate the association between TyG and cardiovascular risk factors and the presence and severity of CS. Methods We recruited 166 patients at Ninh Thuan General Hospital, Vietnam. TyG and HOMA-IR were calculated, and a coronary computed tomography angiography (CCTA) was performed. Results The population was separated according to tertiles of TyG. Patients with highest TyG had higher BMI, waist circumference, total cholesterol, LDL-cholesterol, triglycerides, plasma glucose and HbA1c levels, lower HDL-cholesterol; more of them had a metabolic syndrome and less practiced physical activity (p<0.05 to <0.001). TyG correlated with HOMA-IR (p<0.001). CS ≥50% were present in 60 patients, with a coronary artery narrowing ≥70% in 32 of them. The patients with CS had higher TyG (p<0.05). The association of TyG with CS remained significant in a multivariate analysis including confounding risk factors. The number of narrowed vessels and the degree of stenosis were associated with higher TyG levels (p=0.04 and <0.005). TyG was significant in identifying patients with CS with an area under the ROC curve of 0.678 (95%CI: 0.582-0.775, p=0.002), a cut-off point of 9.63 offering 75% sensitivity and 44% specificity. In subgroup analysis the association TyG-CS was stronger in patients ≥60 yrs, with HbA1c≥7%, on statin or anti-platelet therapy. The AROC was higher with the triple criterion age-HbA1c-TyG than with age or HbA1c alone (p<0.001 for both comparisons). Conclusion More than one third of asymptomatic patients with type 2 diabetes had CS on CCTA. TyG may be considered as a marker of insulin resistance and allows to identify patients with high risk of coronary stenoses, particularly in those ≥ 60 yrs with poor glycemic control, and is associated with the number and the severity of narrowed branches.

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“…When compared to clamp, TyG index could even perform better than HOMA-IR (25). TyG index was also reported to be a marker of metabolic disorders (7,14,26) and a good predictor of incident type 2 diabetes (27)(28)(29). In our population of patients with type 2 diabetes, higher TyG index was strongly associated with higher HOMA-IR and more pronounced metabolic disorders including higher BMI, increased waist circumference, total cholesterol, triglycerides, LDL-cholesterol, non-HDL cholesterol, plasma glucose and HbA1c levels, lower HDLcholesterol levels and also less physical activity.…”

Section: Tyg Index As a Marker Of Insulin Resistance And Metabolic Symentioning

confidence: 99%

Triglyceride Glucose Index for the Detection of Asymptomatic Coronary Artery Stenosis in Patients With Type 2 Diabetes

Thai

Tien

Minh³

et al. 2020

Preprint

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Background: Triglyceride Glucose (TyG) index has been associated with an increased risk in cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country, the burden of cardiovascular disease is growing simultaneously with the epidemiologic transition. Our aim was to assess the prevalence of coronary stenoses (CS) in patients with type 2 diabetes and no history or symptom of cardiovascular disease and to investigate the association between TyG index and cardiovascular risk factors and both the presence and severity of CS. Futhermore, we assessed the value of TyG index in predicting subclinical CS. Methods: This was a cross-sectional observational study. We recruited 166 patients at Ninh Thuan General Hospital, Vietnam. TyG index and HOMA-IR were calculated, and a coronary computed tomography angiography (CCTA) was performed.Results: The population was classified according to tertiles of TyG index. The highest TyG values were associated with higher BMI, waist circumference, total cholesterol, LDL-cholesterol, triglycerides, plasma glucose, HbA1c levels and HOMA-IR, lower HDL-cholesterol, a higher incidence of metabolic syndrome and less frequent physical activity (p<0.05 to <0.0001). TyG index correlated with logHOMA-IR (p<0.0001). CS ≥50% were present in 60 participants and 32 had coronary artery stenosis ≥70%. TyG index and HOMA-IR were significantly higher in patients with CS ≥70%. The number of narrowed coronary arteries and the degree of stenosis were associated with higher TyG index levels (p=0.04 and <0.005 respectively). A TyG index ≥ 10 was significantly associated with an increased risk of multiple coronary artery disease and of more severe CS. After adjusting for confounding factors, including logHOMA-IR, these risks remained mostly significant. A TyG index threshold at 10 resulted in 57% sensitivity and 75% specificity for predicting the presence of CS ≥ 70%. In subgroup analysis TyG index ≥ 10 was associated with an increased risk in CS ≥ 70% in patients treated with statin or antiplatelet therapy.Conclusion: More than one third of asymptomatic patients with type 2 diabetes had significant CS on CCTA. TyG index may be considered as a marker for insulin resistance and increased TyG index could identify patients with high risk of coronary artery stenoses and is associated with the number and the severity of artery stenoses.

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Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study

Cited by 53 publications

References 53 publications

Objectives, design and main findings until 2020 from the Rotterdam Study

Objectives, design and main findings until 2020 from the Rotterdam Study

Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

Triglyceride Glucose Index for the Detection of Asymptomatic Coronary Artery Stenosis in Patients With Type 2 Diabetes

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