Novel memory mutants in Drosophila: Behavioral characteristics of the mutant nemy
                     
                        P153

Kamyshev, N. G.; Iliadi, Konstantin G.; Bragina, Julia V; Kamysheva, Elena A; Tokmatcheva, Elena V.; Préat, Thomas; Савватеева-Попова, Е. В.

doi:10.1186/1471-2202-3-9

Cited by 17 publications

(9 citation statements)

References 49 publications

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“…Short-term memory (STM), lasting on the order of hours, is produced by single training trials or multiple training trials that are not separated in time. STM requires no transcriptional Joiner and Griffith 1997, 2000Kane et al 1997;Savvateeva et al 2000;Sitnik et al 2003;Dukas 2005Kamyshev et al 1999, 2000Kamyshev 2003 Keleman et al 2007 mated-immobile Ejima et al 2005;Kamyshev et al 1999, 2000virgin Kane et al 1997O'Dell et al 1999;McBride et al 1999McBride et al , 2005Reif et al 2002;Dukas 2005 McBride et al 1999; Presente et al 2004 virgin-immobile Siegel and Hall 1979;Tompkins et al 1983;Gailey et al 1984;Cowan and Siegel 1984;Zawistowski 1988;Griffith et al 1993;Joiner and Griffith 1997, 2000Diagana et al 2002;Griffith 2004, 2006;Siwicki et al 2005;Ejima et al 2005;Kamyshev et al 1999Kamyshev et al , 2000Kamyshev et al , 2002 ) chamber where the male would be in almost constant contact with the mated female. Manipulation of the training conditions by increasing the size of the chamber (which allows the male to occasionally ''escape'' the mated female, creating a rest period, see Table 1) or by periodically removing the mated female has been shown to generate a memory that can last up to 8 d (McBride et al 1999).…”

Section: Courtship Behavior Engages Multiple Sensory Systemsmentioning

confidence: 99%

Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior

Griffith¹,

Ejima²

2009

Learn. Mem.

111

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Mechanisms for identifying appropriate mating partners are critical for species propagation. In many species, the male uses multiple sensory modalities to search for females and to subsequently determine if they are fit and receptive. Males can also use the information they acquire in this process to change their courtship behavior and reduce courtship of classes of targets that are inappropriate or unreceptive. In Drosophila, courtship plasticity, in the form of both nonassociative and associative learning, has been documented-the type of learning depending on the nature of the trainer. The conditions in which the male is presented with the training target can profoundly alter the cues that he finds salient and the longevity of the memory that he forms. With the exception of habituation and sensitization, these types of plasticity have an operant component in that the male must be courting to respond to the behavior-altering cues. Courtship plasticity is therefore a complex and rich range of behaviors rather than a single entity. Our understanding of these plastic behaviors has been enhanced by recent advances in our understanding of the circuitry underlying courtship itself and the identification of chemical cues that drive and modify the behavior. Courtship learning is providing a window into how animals can use a variety of sensory inputs to modulate a decision making process at many levels.

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Section: Courtship Behavior Engages Multiple Sensory Systemsmentioning

confidence: 99%

Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior

Griffith¹,

Ejima²

2009

Learn. Mem.

111

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“…Learning and memory have been demonstrated in various social contexts in fruit flies as well (6,(8)(9)(10)(11). We have been studying aggression as a behavior indicative of individual fitness in fruit flies and other organisms.…”

mentioning

confidence: 99%

Learning and memory associated with aggression in Drosophila melanogaster

Yurkovic

Wang

Basu

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

128

144

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Male Drosophila melanogaster (Canton-S strain) exhibit aggression in competition for resources, to defend territory, and for access to mates. In the study reported here, we asked: (i) how long flies fight; (ii) whether flies adopt distinct winning and losing strategies as hierarchical relationships are established; (iii) whether flies exhibit experience-dependent changes in fighting strategies in later fights; and (iv) whether flies fight differently in second fights against familiar or unfamiliar opponents. The results showed that flies fought for up to 5 h. As hierarchical relationships were established, behavioral strategies changed: winners progressively lunged more and retreated less, whereas losers progressively lunged less and retreated more. Encounters between flies were frequent during the first 10 min of pairing and then dropped significantly. To ask whether flies remembered previous fights, they were re-paired with familiar or unfamiliar opponents after 30 min of separation. In familiar pairings, there were fewer encounters during the first 10 min of fighting than in unfamiliar pairings, and former losers fought differently against familiar winners than unfamiliar winners. Former losers lost or no decision was reached in all second fights in pairings with familiar or unfamiliar winners or with naive flies. Winner͞winner, loser͞loser, and naive͞naive pairings revealed that losers used low-intensity strategies in later fights and were unlikely to form new hierarchical relationships, compared with winners or socially naive flies. These results strongly support the idea that learning and memory accompany the changes in social status that result from fruit fly fights.behavior ͉ dominance ͉ fruit fly ͉ social status ͉ fighting

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“…nemy was originally generated in a forward genetic screen for mutants affecting courtship memory [ 34 ]. A more thorough characterization showed that in addition to defects in courtship memory, nemy mutants also have a defect in middle-term olfactory memory [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy

Knight

Iliadi

et al. 2015

PLoS ONE

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Synaptic transmission is highly plastic and subject to regulation by a wide variety of neuromodulators and neuropeptides. In the present study, we have examined the role of isoforms of the cytochrome b561 homologue called no extended memory (nemy) in regulation of synaptic strength and plasticity at the neuromuscular junction (NMJ) of third instar larvae in Drosophila. Specifically, we generated two independent excisions of nemy that differentially affect the expression of nemy isoforms. We show that the nemy 45 excision, which specifically reduces the expression of the longest splice form of nemy, leads to an increase in stimulus evoked transmitter release and altered synaptic plasticity at the NMJ. Conversely, the nemy 26.2 excision, which appears to reduce the expression of all splice forms except the longest splice isoform, shows a reduction in stimulus evoked transmitter release, and enhanced synaptic plasticity. We further show that nemy 45 mutants have reduced levels of amidated peptides similar to that observed in peptidyl-glycine hydryoxylating mono-oxygenase (PHM) mutants. In contrast, nemy 26.2 mutants show no defects in peptide amidation but rather display a decrease in Tyramine β hydroxylase activity (TβH). Taken together, these results show non-redundant roles for the different nemy isoforms and shed light on the complex regulation of neuromodulators.

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Novel memory mutants in Drosophila: Behavioral characteristics of the mutant nemy P153

Cited by 17 publications

References 49 publications

Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior

Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior

Learning and memory associated with aggression in Drosophila melanogaster

Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy

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