Dendritic cells (DC) are important orchestrators of the immune response, ensuring that immunity against pathogens is generated while immunity against healthy tissues is prevented. Using the tumor Ag MUC1, we previously showed that i.v. immunization of MUC1.Tg mice, but not WT, with a MUC1 peptide resulted in transient tolerization of all splenic DC. These DC did not upregulate costimulatory molecules and induced regulatory T cells (Treg) rather than effector T cells. They were characterized by suppressed expr…
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