Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo‐Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC‐1 Cells via GPR40

Hira, Tohru; Ogasawara, Shono; Yahagi, Asuka; Kamachi, Minami; Li, Jiaxin; Nishimura, Saki; Sakaino, Masayoshi; Yamashita, Takatoshi; Kishino, Shigenobu; Ogawa, Jun; Hara, Hiroshi

doi:10.1002/mnfr.201800146

Cited by 15 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, compared with wild-type mice, FFAR1-deficient mice exhibited decreased CCK secretion in response to olive oil gavage (187). Interestingly, Hira et al (115) indicated that FAs such as 10-oxo-trans-11…”

Section: Insulin and Gut Hormone Secretionmentioning

confidence: 99%

Free Fatty Acid Receptors in Health and Disease

Kimura

Ichimura

Ohue‐Kitano

et al. 2020

Physiological Reviews

528

482

View full text Add to dashboard Cite

Fatty acids are metabolized and synthesized as energy substrates during biological responses. Long- and medium-chain fatty acids derived mainly from dietary triglycerides, and short-chain fatty acids (SCFAs) produced by gut microbial fermentation of the otherwise indigestible dietary fiber, constitute the major sources of free fatty acids (FFAs) in the metabolic network. Recently, increasing evidence indicates that FFAs serve not only as energy sources but also as natural ligands for a group of orphan G protein-coupled receptors (GPCRs) termed free fatty acid receptors (FFARs), essentially intertwining metabolism and immunity in multiple ways, such as via inflammation regulation and secretion of peptide hormones. To date, several FFARs that are activated by the FFAs of various chain lengths have been identified and characterized. In particular, FFAR1 (GPR40) and FFAR4 (GPR120) are activated by long-chain saturated and unsaturated fatty acids, while FFAR3 (GPR41) and FFAR2 (GPR43) are activated by SCFAs, mainly acetate, butyrate, and propionate. In this review, we discuss the recent reports on the key physiological functions of the FFAR-mediated signaling transduction pathways in the regulation of metabolism and immune responses. We also attempt to reveal future research opportunities for developing therapeutics for metabolic and immune disorders.

show abstract

Section: Insulin and Gut Hormone Secretionmentioning

confidence: 99%

Free Fatty Acid Receptors in Health and Disease

Kimura

Ichimura

Ohue‐Kitano

et al. 2020

Physiological Reviews

528

482

View full text Add to dashboard Cite

show abstract

“…This gene’s presence in the microbiome is associated with lower serum cholesterol levels in humans and reduced risk of cardiovascular disease [ 121 ]. An in vitro study in an enteroendocrine cell line demonstrated that the fatty acid receptor GPR40 stimulates potent cholecystokinin (CCK)-release in response to the presence of specific oxo-fatty acids produced by lactic acid bacteria [ 122 ]. CCK and secretin are two peptide hormones that regulate the emulsification and digestion of fat through the release of pancreatic enzymes and control over gastric emptying.…”

Section: Microbes Metabolize Dietary Lipidsmentioning

confidence: 99%

Chewing the Fat with Microbes: Lipid Crosstalk in the Gut

Lemons

Liu

2022

Nutrients

View full text Add to dashboard Cite

It is becoming increasingly important for any project aimed at understanding the effects of diet on human health, to also consider the combined effect of the trillions of microbes within the gut which modify and are modified by dietary nutrients. A healthy microbiome is diverse and contributes to host health, partly via the production and subsequent host absorption of secondary metabolites. Many of the beneficial bacteria in the gut rely on specific nutrients, such as dietary fiber, to survive and thrive. In the absence of those nutrients, the relative proportion of good commensal bacteria dwindles while communities of opportunistic, and potentially pathogenic, bacteria expand. Therefore, it is unsurprising that both diet and the gut microbiome have been associated with numerous human diseases. Inflammatory bowel diseases and colorectal cancer are associated with the presence of certain pathogenic bacteria and risk increases with consumption of a Western diet, which is typically high in fat, protein, and refined carbohydrates, but low in plant-based fibers. Indeed, despite increased screening and better care, colorectal cancer is still the 2nd leading cause of cancer death in the US and is the 3rd most diagnosed cancer among US men and women. Rates are rising worldwide as diets are becoming more westernized, alongside rising rates of metabolic diseases like obesity and diabetes. Understanding how a modern diet influences the microbiota and how subsequent microbial alterations effect human health will become essential in guiding personalized nutrition and healthcare in the future. Herein, we will summarize some of the latest advances in understanding of the three-way interaction between the human host, the gut microbiome, and the specific class of dietary nutrients, lipids.

show abstract

“…In addition to modulating CCK expression, microbiome may influence CCK release. In the murine EEC line STC-1, application of certain fatty acid metabolites produced by commensal lactic acid bacteria results in increased CCK release [ 70 ].…”

Section: Microbiome Composition Influences Peripheral Intake Mechanismsmentioning

confidence: 99%

Microbiota’s Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward

Rautmann

Serre

2021

Nutrients

View full text Add to dashboard Cite

The gut microbiota plays a key role in modulating host physiology and behavior, particularly feeding behavior and energy homeostasis. There is accumulating evidence demonstrating a role for gut microbiota in the etiology of obesity. In human and rodent studies, obesity and high-energy feeding are most consistently found to be associated with decreased bacterial diversity, changes in main phyla relative abundances and increased presence of pro-inflammatory products. Diet-associated alterations in microbiome composition are linked with weight gain, adiposity, and changes in ingestive behavior. There are multiple pathways through which the microbiome influences food intake. This review discusses these pathways, including peripheral mechanisms such as the regulation of gut satiety peptide release and alterations in leptin and cholecystokinin signaling along the vagus nerve, as well as central mechanisms, such as the modulation of hypothalamic neuroinflammation and alterations in reward signaling. Most research currently focuses on determining the role of the microbiome in the development of obesity and using microbiome manipulation to prevent diet-induced increase in food intake. More studies are necessary to determine whether microbiome manipulation after prolonged energy-dense diet exposure and obesity can reduce intake and promote meaningful weight loss.

show abstract

Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo‐Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC‐1 Cells via GPR40

Abstract: These results reveal a novel fatty acid-sensing mechanism in enteroendocrine cells.

Cited by 15 publications

References 35 publications

Free Fatty Acid Receptors in Health and Disease

Free Fatty Acid Receptors in Health and Disease

Chewing the Fat with Microbes: Lipid Crosstalk in the Gut

Microbiota’s Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward

Contact Info

Product

Resources

About