Novel MCR Synthesis of Post Transition Metal Complexes with Substituted Hydroxy Quinolines as Potent Antimicrobial Agent

Abstract

Metal complexes with substituted quinolines especially copper, zinc and nickel complexes significantly reduce the decay of wood, cellulose and hemi cellulose, caused by fungi and used for wood preservative 1. A process for treating such materials with these copper-containing antifungal agents is also disclosed. Copper(II)-complexes have octahedral, square pyramid and square planar geometries. They also reflect the strong coordinating ability for NO 3-, Cl-, Br-, AcOand SO 4 2-, depending on the type of the anions. The zinc complexes of selected amino acids like proline, lysine, histidine, glycine and arginine can be used for inhibition of growth for the malarial parasite i.e., Plasmodium falciparum. Zinc(II) complex has been shown to exhibit antimicrobial activity and ameliorate hyper insulinemia and massive hereditary obesity in mice. In addition to structural activity relationships of zinc complexes improved hyperglycemia and insulin resistance in diabetic mice. Zinc(II) complex actually triggered the development of new zinc complexes with anti-metabolic syndrome activity. Nickel occurs in various oxidation states and find wide applications in number of synthetic and biological mechanisms. A series of nickel complexes have been synthesized and employed for biological and fungal activities against different bacterial and fungal species 2-6. The chelating power of nickel has been enhanced by treating it with several ligands 7. Different