Novel magneto-responsive nanoplatforms based on MnFe2O4 nanoparticles layer-by-layer functionalized with chitosan and sodium alginate for magnetic controlled release of curcumin

Jardim, Katiúscia Vieira; Palomec-Garfias, Abraham Francisco; Andrade, Bárbara Yasmin Garcia; Chaker, Juliano Alexandre; Báo, Sônia Nair; Márquez‐Beltrán, César; Moya, Sergio; Parize, Alexandre Luís; Sousa, Marcelo Henrique

doi:10.1016/j.msec.2018.06.039

Cited by 51 publications

(28 citation statements)

References 56 publications

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“…If one assumes that the magnetic core is preserved after dispersion into the polymeric matrix, the extent of the decrease in M s can be associated with the amount of polymeric material around the NPs. 33 Then, the amount of magnetic material can be estimated to be ∼47.9% in mass, slightly lower than that determined from TGA measurements. Besides, the dosage of iron on the MNP@PVBC sample using ICP-OES allowed estimating a magnetic content of ∼44.5 wt % in γ-Fe 2 O 3 , in close agreement with the magnetization data.…”

Section: Resultsmentioning

confidence: 76%

Highly Magnetizable Crosslinked Chloromethylated Polystyrene-Based Nanocomposite Beads for Selective Molecular Separation of 4-Aminobenzoic Acid

et al. 2019

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In this work, we describe the preparation and characterization of highly magnetizable chloromethylated polystyrene-based nanocomposite beads. For synthesis optimization, acid-resistant core–shelled maghemite (γ-Fe 2 O 3 ) nanoparticles are coated with sodium oleate and directly incorporated into the organic medium during a suspension polymerization process. A crosslinking agent, ethylene glycol dimethacrylate, is used for copolymerization with 4-vinylbenzyl chloride to increase the resistance of the microbeads against leaching. X-ray diffraction, inductively coupled plasma atomic emission spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, and optical microscopy are used for bead characterization. The beads form a magnetic composite consisting of ∼500 nm-sized crosslinked polymeric microspheres, embedding ∼8 nm γ-Fe 2 O 3 nanoparticles. This nanocomposite shows large room temperature magnetization (∼24 emu/g) due to the high content of maghemite (∼45 wt %) and resistance against leaching even in acidic media. Moreover, the presence of superficial chloromethyl groups is probed by Fourier transform infrared and X-ray photoelectron spectroscopy. The nanocomposite beads displaying chloromethyl groups can be used to selectively remove aminated compounds that are adsorbed on the beads, as is shown here for the molecular separation of 4-aminobenzoic acid from a mixture with benzoic acid. The high magnetization of the composite beads makes them suitable for in situ molecular separations in environmental and biological applications.

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Section: Resultsmentioning

confidence: 76%

Highly Magnetizable Crosslinked Chloromethylated Polystyrene-Based Nanocomposite Beads for Selective Molecular Separation of 4-Aminobenzoic Acid

et al. 2019

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“…It was already shown that the ferrite based magnetic particles, mainly Fe 3 O 4 , due to their proven biocompatibility and biodegradability, are attractive in oncological medicine [43,44]. Therefore, development of new multifunctional systems combining magnetic ferrite nanoparticles with anchored hydrophobic drugs is of great importance in modern theranostic applications of cancer treatment [45,46]. This approach allows for construction of smart platforms which functions are directly related to the properties of each constituent.…”

Section: Discussionmentioning

confidence: 99%

AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts

et al. 2020

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Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan. More recently, several categories of senolytics have been established, namely HSP90 inhibitors, Bcl-2 family inhibitors and natural compounds such as quercetin and fisetin. However, senolytic and senostatic potential of nanoparticles and surface-modified nanoparticles has never been addressed. In the present study, quercetin surface functionalized Fe3O4 nanoparticles (MNPQ) were synthesized and their senolytic and senostatic activity was evaluated during oxidative stress-induced senescence in human fibroblasts in vitro. MNPQ promoted AMPK activity that was accompanied by non-apoptotic cell death and decreased number of stress-induced senescent cells (senolytic action) and the suppression of senescence-associated proinflammatory response (decreased levels of secreted IL-8 and IFN-β, senostatic action). In summary, we have shown for the first time that MNPQ may be considered as promising candidates for senolytic- and senostatic-based anti-aging therapies.

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“…This method involves electrostatic interaction between oppositely charged polyelectrolytes, where alternating adsorption of multi-layers cationic and anionic polymers occurs on flat substrates. In addition, this technique enables drug to be embedded between the layers, and hence promoting encapsulation efficiency and drug release control propensity with the reference of the physiochemical properties of the polymeric carrier used [ 92 ]. Layer-by-layer process can be influenced by various factors, such as pH of the medium, saturation adsorption time, polyelectrolyte concentration, adsorption temperature and salt concentration of polyelectrolyte solutions as well as the type of the matrix and core used [ 93 ].…”

Section: Alginate Nanoparticles Preparation Methodsmentioning

confidence: 99%

“…The pKa value of alginate is between 3.4 and 4.4 (depending on its source). At pH > pKa, the carboxylate groups of alginates are ionized (Alg-COO − ) and electrostatically linked to calcium ions and cationic polymers [ 92 ]. Furthermore, the negatively charged carboxylate groups are predominant at weak acid medium around pH = 5 [ 85 ].…”

Section: Factors Influencing Alginate Nanoparticles’ Characteristimentioning

confidence: 99%

Alginate Nanoformulation: Influence of Process and Selected Variables

2020

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Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance, as well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and biomedical applications as a matrix material of nanocarriers due to its inherent biological properties, including good biocompatibility and biodegradability. Various techniques have been adopted to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and cost-effective properties. This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the main processing and formulation parameters on alginate nanoparticles are also summarized.

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Novel magneto-responsive nanoplatforms based on MnFe2O4 nanoparticles layer-by-layer functionalized with chitosan and sodium alginate for magnetic controlled release of curcumin

Cited by 51 publications

References 56 publications

Highly Magnetizable Crosslinked Chloromethylated Polystyrene-Based Nanocomposite Beads for Selective Molecular Separation of 4-Aminobenzoic Acid

Highly Magnetizable Crosslinked Chloromethylated Polystyrene-Based Nanocomposite Beads for Selective Molecular Separation of 4-Aminobenzoic Acid

AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts

Alginate Nanoformulation: Influence of Process and Selected Variables

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