Novel low temperature (&lt;37 °C) chitosan hydrogel fabrication under the synergistic effect of graphene oxide

Dai, Zhonghua; Lu, Qin; Qinguo, Quan; Mo, Rijian; Zhou, Chunxia; Hong, Pengzhi; Li, Chengyong

doi:10.1039/c6nj03509d

Cited by 11 publications

(5 citation statements)

References 46 publications

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“…A low-temperature CS hydrogel was fabricated via a simple mixing method, under the synergistic effect of GO and β-glycerophosphate (GP) by Dai et al. (2017) .…”

Section: Wound Healingmentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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Summary Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers . Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.

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“…A low-temperature CS hydrogel was fabricated via a simple mixing method, under the synergistic effect of GO and β-glycerophosphate (GP) by Dai et al. (2017) .…”

Section: Wound Healingmentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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“…Using β-glycerophosphate (GP) enzyme as a crosslinker and Tris(2,2bipyridyl)dichlororuthenium(II) as an anticancer agent, researchers created a unique low-temperature hydrogel of CS/GO [113]. The scaffold was made by combining GO, CS, and GP in various ratios, with the addition of acetic acid to improve CS solubility.…”

Section: Enzyme-driven Synthesis Methodsmentioning

confidence: 99%

A Review on Synthesis Methods of Phyllosilicate- and Graphene-Filled Composite Hydrogels

Ganguly

Margel

2022

J. Compos. Sci.

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This review discusses, in brief, the various synthetic methods of two widely-used nanofillers; phyllosilicate and graphene. Both are 2D fillers introduced into hydrogel matrices to achieve mechanical robustness and water uptake behavior. Both the fillers are inserted by physical and chemical gelation methods where most of the chemical gelation, i.e., covalent approaches, results in better physical properties compared to their physical gels. Physical gels occur due to supramolecular assembly, van der Waals interactions, electrostatic interactions, hydrophobic associations, and H-bonding. For chemical gelation, in situ radical triggered gelation mostly occurs.

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“…The preparation of GO was according to modified Hummers method [ 26 , 27 ]. Briefly, K 2 S 2 O 8 (1 g), P 2 O 5 (1 g) and graphite (2 g) were added into round bottomed flask (250 mL), and sulfuric acid (98%, 10 mL) were slowly added, then heated at 80 °C for 6 h. After that, the mixture was cooled to room temperature and diluted with distilled water carefully.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Determination of Nitrite by Au Nanoparticle/Graphene-Chitosan Modified Electrode

Yuan

Yan

et al. 2018

Sensors

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A highly sensitive nitrite (NO2−) electrochemical sensor is fabricated using glassy carbon electrode modified with Au nanoparticle and grapheme oxide. Briefly, this electrochemical sensor was prepared by drop-coating graphene oxide-chitosan mixed film on the surface of the electrode and then electrodepositing a layer of Au nanoparticle using cyclic voltammetry. The electrochemical behavior of NO2− on the sensor was investigated by cyclic voltammetry and amperometric i-t curve. The results showed that the sensor exhibited better electrocatalytic activity for NO2− in 0.1 mol/L phosphate buffer solution (PBS) (pH 5.0). The oxidation peak current was positively correlated with NO2− concentration in the ranges of 0.9 µM to 18.9 µM. The detection limit was estimated to be 0.3 µM. In addition, the interference of some common ions (e.g., NO3−, CO32−, SO42−, Cl−, Ca2+ and Mg2+) and oxidizable compound including sodium sulfite and ascorbic acid in the detection of nitrite was also studied. The results show that this sensor is more sensitive and selective to NO2−. Therefore, this electrochemical sensor provided an effective tool for the detection of NO2−.

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Novel low temperature (<37 °C) chitosan hydrogel fabrication under the synergistic effect of graphene oxide

Abstract: A low temperature chitosan hydrogel was fabricated under the synergistic effect of graphene oxide, and may be applied in hydrogel medical coatings.

Cited by 11 publications

References 46 publications

Biomedical applications of chitosan-graphene oxide nanocomposites

Biomedical applications of chitosan-graphene oxide nanocomposites

A Review on Synthesis Methods of Phyllosilicate- and Graphene-Filled Composite Hydrogels

Electrochemical Determination of Nitrite by Au Nanoparticle/Graphene-Chitosan Modified Electrode

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