Novel low-kVp beamlet system for choroidal melanoma

Esquivel, Carlos O.; Fuller, Clifton D.; Waggener, Robert G.; Wong, Angelique; Meltz, Martin L.; Blough, Melissa M.; Eng, Tony Y.; Thomas, Charles R.

doi:10.1186/1748-717x-1-36

Cited by 3 publications

(8 citation statements)

References 21 publications

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“…For example, some reported average dose, some point dose. Esquivel et al 8 and Thomson et al 42 did not show DVH, and Lesperance et al 34 only showed the DVHs of the tumor and lens. Some relevant points of the studies are discussed in the remarks of Tables V and VI.…”

Section: B Comparison To Previous Publicationsmentioning

confidence: 96%

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Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement

Sun

et al. 2018

Medical Physics

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Compared to eye plaque brachytherapy, the proposed focused kV x-ray technique is noninvasive and shows great advantage in sparing healthy critical organs without sacrificing the tumor control. The NP radiation dose enhancement is considerable at our proposed kV range even with a low NP concentration in the tumor, providing better critical structure protection and more flexibility for treatment planning.

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Section: B Comparison To Previous Publicationsmentioning

confidence: 96%

“…We compared our simulation results of choroid melanoma treatment to Esquivel et al 8 and Lesperance et al 34 in FIG. 11.…”

Section: B Comparison To Previous Publicationsmentioning

confidence: 99%

Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement

Sun

et al. 2018

Medical Physics

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“…Iwamoto et al 42 have reported on the treatment of canine brain tumors using kilovoltage x rays from a modified computed tomography scanner. Also, the theoretical work of Esquivel et al 43 highlights a novel small beamlet system using an isocentrically mounted x-ray tube operating at 70 kVp for the treatment of ocular disease. The experimental validation of such irradiation devices could make use of a dose imaging system proven to resolve steep dose gradients at the micron level.…”

Section: Discussionmentioning

confidence: 99%

Optical imaging analysis of microscopic radiation dose gradients in Gafchromic EBT film using a digital microscope

2008

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By providing superior localization and immobilization, stereotactic radiosurgery (SRS) is capable of delivering millimeter spheres of dose to intracranial targets with submillimeter precision. Several authors have proposed new SRS solutions to dramatically reduce beam penumbra to hundreds of microns. These solutions require new quality assurance methods capable of penumbra measurement at the micron scale. This article examines the capability of a digital microscope, with translation stage and associated software, to resolve dose gradients in Gafchromic EBT film at this level. To produce very steep penumbra, films were irradiated in phantom beneath pinhole collimators using lower energy x rays (100 kVp, 300 kVp, and Iridium-192) and minimal geometric penumbra contribution. For film analysis, a method was developed which improved the signal to noise ratio by finding the center of the irradiation spot, generating several radial dose profiles and averaging these to obtain the final off-axis dose profile. Optical density was converted to dose using a calibration curve. The experimentally determined off-axis dose profiles were compared with MCNP Monte Carlo simulations which replicated the irradiation geometry and served to validate our measured data. The measured 80%-20% penumbral widths were 46 microm +/- 26 microm (100 kVp, 2 mm field size), 69 microm +/- m 27 microm (300 kVp, 2 mm field size), and 241 microm +/-31 microm (Ir-192, 1 mm field size). These penumbral widths agreed with Monte Carlo simulations within experimental uncertainty. Our findings suggest that reading Gafchromic EBT films using a digital microscope with translation stage is suitable for the quality assurance of very sharp penumbra able to resolve gradients to within at least 30 microm.

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“…The investigated radiotherapy sources included:I-125 and Pd-103, chosen as typical low energy plaque brachy-therapy sources described in TG-43, the Oraya Therapy system with100 kVp energies [14], and the Beamlet Low-kVp X-ray (BLOKX)system with 90 kVp beams [7], developed specifically for treating ocular diseases. The SpekCalc program was used to generate the external energy spectra for the external beam sources, as in previous studies [6][15].…”

Section: Methodsmentioning

confidence: 99%

“…It was shown that, AuNPs could provide a major localized dose enhancement to the diseased endothelial cell (EC) during Oraya therapy. In another study, Monte Carlo radiation transport simulation was used to investigate the use of a small collimated external beam of low energy x-rays (BLOKX system) for the treatment of medium size CM and it was shown that this system can deliver a more conformal dose to the tumor site in comparison to standard plaque therapy [7]. …”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-aided Radiotherapy for Retinoblastoma and Choroidal Melanoma

et al. 2015

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This work investigates the dosimetric feasibility of employing gold nanoparticles (AuNPs) or carboplatin nano-particles (CNPs) to enhance radiotherapy (RT) treatment efficacy for ocular cancers: retinoblastoma (Rb) and choroidal melanoma (CM), during kV-energy internal and external beam radiotherapy. The results predict that substantial dose enhancement may be achieved by employing AuNPs or CNPs in conjunction with radiotherapy for ocular cancer using kV-energy photon beams. Brachytherapy sources yield higher dose enhancement than the external beam in kV energy range. However, the external beam has the advantage of being non-invasive

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Novel low-kVp beamlet system for choroidal melanoma

Cited by 3 publications

References 21 publications

Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement

Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement

Optical imaging analysis of microscopic radiation dose gradients in Gafchromic EBT film using a digital microscope

Nanoparticle-aided Radiotherapy for Retinoblastoma and Choroidal Melanoma

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