Novel Lipid Thresholds for Screening Predict the Need for Pharmacotherapy

Zawacki, Amy; Dodge, Ann; Eickhoff, Jens; Sun, Wendy; Marriott, Erin; Ralphe, J. Carter; Peterson, Amy L.

doi:10.1016/j.jpeds.2018.07.008

Cited by 3 publications

(1 citation statement)

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“…The role of oxidative stress in the occurrence and progression of cardiovascular disease has been proven. As the free radicals are released in quantities that exceed the body's ability to neutralize them, this leads to the oxidation of fatty substances, mainly cholesterol, and its deposition in the lining of the arteries, which leads to the emergence of many diseases related to the heart and blood vessels, including myocardial infarction (7) and antioxidants work It protects the body from oxidative stress by reducing the concentrations of free radicals and scavenging them, such as glutathione and super-oxide dismutase, or by preventing the formation of chain reactions that form free radicals, in addition to stopping their spread such as vitamin E and vitamin C (8). Studies have indicated the role of antioxidants in the treatment or prevention of heart disease and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Purification of alkaline phosphatase and measurement of some antioxidants in the serum of patients with high blood cholesterol

2023

JPTCP

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This study included the purification of the alkaline phosphatase and the estimation of the level of antioxidants in the serum of people .Those with high cholesterol. 33 blood samples were collected from people with high cholesterol in the blood of both sexes, with ages ranging between (60-42 years), and 20 blood samples were collected from people with normal cholesterol levels for both sexes. The alkaline phosphatase was also purified, as the degree of purification of the enzyme in the purification stage reached 2.7 times, with an enzymatic yield of 42.2%, and then using the gel filtration chromatography method using Sephadex G100 gel, as a single peak was obtained for the purified enzyme as ,with a degree of purification that reached 3.8 times and an enzymatic yield of 22%. High cholesterol leads to cardiovascular disease. The results a Significat increase in activity of ALP ,Cholestrol ,Lipoprotiens, catales,uric acid. The decrease total protie and Glutathion

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Section: Introductionmentioning

confidence: 99%