“…6–13 Despite its great potency in killing cancer cells, TQ application has often raised several concerns related to its relatively low solubility in water and its rapid elimination after serum opsonin binding, leading to a considerable decease of its bioavailability and pharmacological activity. 14–16 To deal successfully with these drawbacks, numerous studies have tried to encapsulate TQ into organic nanocarriers, used as delivery systems, like lipid-coated mesoporous silica nanoparticles, 17 chitosan-solid lipid nanoparticles, 18 and lipid nanocapsules. 19 Indeed, owing to their high surface and volume ratio, nanocarriers are able to modify the basic properties and to enhance both drug solubility and stability 20,21 and improve drug pharmacokinetics and biodistribution.…”