Novel lipid based oral formulation of curcumin: Development and optimization by design of experiments approach

Pawar, Yogesh B.; Purohit, Hitesh S.; Valicherla, Guru R.; Munjal, Bhushan; Lale, Shantanu V.; Patel, Sarsvatkumar; Bansal, Arvind K.

doi:10.1016/j.ijpharm.2012.07.031

Cited by 55 publications

(28 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…intrinsic permeability, effective permeability and wall permeability, the OPT S-SNEDDS exhibited nearly 53, 52 and 227% increase, followed by the inclusion complex showing nearly 21, 9 and 30% rise, whereas in case of the MKT formulation, only 14, 7 and 21% enhancement was observed as compare to the pure drug. This confirmed significant improvement in permeability parameters of OPT S-SNEDDS, especially in wall permeability, ostensibly ascribed to the synergistic effect of lipid and emulgent present in the formulation (Pawar et al, 2012).…”

Section: In Situ Intestinal Perfusion Studiessupporting

confidence: 64%

QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance

et al. 2014

View full text Add to dashboard Cite

(2015) QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance, Drug Delivery, 22:6, 765-784, DOI: 10.3109/10717544.2014 AbstractOf late, solid self-nanoemulsifying drug delivery systems (S-SNEDDS) have been extensively sought-after owing to their superior portability, drug loading, stability and patient compliance. The current studies, therefore, entail systematic development, optimization and evaluation (in vitro, in situ and in vivo) of the solid formulations of (SNEDDS) lovastatin employing rational quality by design (QbD)-based approach of formulation by design (FbD). The patient-centric quality target product profile (QTPP) and critical quality attributes (CQAs) were earmarked. Preformulation studies along with initial risk assessment facilitated the selection of lipid (i.e. Capmul MCM), surfactant (i.e. Nikkol HCO-50) and co-surfactant (i.e. Lutrol F127) as CMAs for formulation of S-SNEDDS. A face-centered cubic design (FCCD) was employed for optimization using Nikkol-HCO50 (X 1 ) and Lutrol-F127 (X 2 ), evaluating CQAs like globule size, liquefaction time, emulsification time, MDT, dissolution efficiency and permeation parameter. The design space was generated using apt mathematical models, and the optimum formulation was located, followed by validation of the FbD methodology. In situ SPIP and in vivo pharmacodynamic studies on the optimized formulation carried out in unisex Wistar rats, corroborated superior drug absorption and enhanced pharmacodynamic potential in regulating serum lipid levels. In a nutshell, the present studies report successful QbD-oriented development of novel oral S-SNEDDS of lovastatin with distinctly improved biopharmaceutical performance.

show abstract

Section: In Situ Intestinal Perfusion Studiessupporting

confidence: 64%

QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance

et al. 2014

View full text Add to dashboard Cite

show abstract

“…CRM concentrations in the brain homogenate were determined using the HPLC system as reported by Pawar et al (2012). The drug concentration in plasma was analyzed by a high-performance liquid chromatography (HPLC) method using the Rheodine type manual injector.…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study

2014

View full text Add to dashboard Cite

Cancer nanotherapeutics is beginning to overwhelm the global research and viewed to be the revolutionary treatment regime in the medical field. This investigation describes the development of a stable nanostructured lipid carrier (NLC) system as a carrier for curcumin (CRM). The CRM-loaded NLC developed as a particle with the size of 146.8 nm, a polydispersity index of 0.18, an entrapment efficiency (EE) of 90.86%, and the zeta potential (ZP) of À21.4 mV. Besides, the increased cytotoxicity of CRM-NLC than that of CRM to astrocytoma-glioblastoma cell line (U373MG) in the cancer cell lines was observed. Results of biodistribution studies showed higher drug concentration in brain after intranasal administration of NLCs than PDS. The results of the study also suggest that CRM-NLC is a promising drug delivery system for brain cancer therapy. KeywordsCurcumin, nanostructured lipid carrier, nasal drug delivery History

show abstract

“…The multidimensional combination and interaction of independent variables and process parameters, that have been confirmed to offer assurance of quality, is term as the design space [3,33]. Design space may possibly be determined from the common region of doing well operational range designed for the two responses.…”

Section: Experimental Validation Of Design Spacementioning

confidence: 99%

Optimization and Formulation Development of Cefixime Complex Using Spray Drying Technique: DOE Approach

Mogal¹,

Derle²

2017

J Appl Pharm

View full text Add to dashboard Cite

Cefixime is BCS class 2/4 drug whose oral absorption is limited by its solubility and/or permeability. The use of HPBCD is proved to be better complexing agent for enhancing solubility as well as permeability of drugs. At the same time spray drying is the one step continuous drying process making it attractive technique for industrial application. Therefore, the current study was undertaken to unite the use of HPBCD and spray drying alongside with optimizing it through Design of Experiments (DOE) approach by means of Box-Behnken design for the benefit of drugs like Cefixime that needs to be redeveloped for better therapeutic efficacy. These formulations were evaluated by solubility studies, process yield and total drug content with help of independent variables like air inlet temperature, aspirator rate and pump feed rate. The optimized formulation was also characterized by SEM, FTIR analysis and in vitro dissolution study. Inlet air temperature was found to be the most important parameter for the spray dried material characteristics, followed by the aspirator flow rate whereas Feed flow rate was found less significant. The results indicate that formulation parameters are at least important than process parameters when designing a proper process for spray drying inclusion complex. The optimized formulation was also then compressed into tablet and was compared with marketed formulation where it showed comparable dissolution.

show abstract

Novel lipid based oral formulation of curcumin: Development and optimization by design of experiments approach

Cited by 55 publications

References 15 publications

QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance

QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance

Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study

Optimization and Formulation Development of Cefixime Complex Using Spray Drying Technique: DOE Approach

Contact Info

Product

Resources

About