Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of .MU.-Opioid Receptor Gene in Japanese Population

Ono, Takeshi; Muto, Akihiro; Kaneda, Toshio; Arita, Eri; Yoshida, Tadashi

doi:10.1248/bpb.32.721

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…These changes alter the functional properties of the receptor for opioids and lead to variability in the analgesic effect of opioids [ 17 ]. The frequency of the minor allele (118G) has been reported variously from 0.01 to 0.5 according to ethnicity [ 16 18 ]. It appears to be relatively high in Asian populations, and our study reveals the frequency as 0.375.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

et al. 2016

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BackgroundAlthough opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children.MethodsA prospective study was conducted in 88 healthy children undergoing tonsillectomy, who received morphine during the operation. The postoperative pain score, frequency of rescue analgesics, and side effects of morphine were assessed in the post-anesthesia care unit. The children were genotyped for OPRM1 A118G, ABCB1 C3435T, and COMT Val158Met.ResultsChildren with at least one G allele for OPRM1 (AG/GG) had higher postoperative pain scores compared with those with the AA genotype at the time of discharge from the post-anesthesia care unit (P = 0.025). Other recovery profiles were not significantly different between the two groups. There was no significant relationship between genotypes and postoperative pain scores in analysis of ABCB1 and COMT polymorphisms.ConclusionsGenetic polymorphism at OPRM1 A118G, but not at ABCB1 C3435T and COMT Val158Met, influences the analgesic effect of morphine for immediate acute postoperative pain in children.

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Section: Discussionmentioning

confidence: 99%

The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

et al. 2016

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“…Numerous SNPs have been described in the regulatory region, some of which are population-specific (Hoehe et al 2000; Ono et al 2009b), and several have been functionally characterized. Two promoter polymorphisms, -554G>A and -1320A>G, have been shown to affect transcription (Bayerer et al 2007).…”

Section: The Mu Opioid Receptor Gene (Oprm1)mentioning

confidence: 99%

“…The Poly (ADP-ribose) polymerase-1 (PARP-1) was shown to preferentially bind to the -172T allele and positively regulate OPRM1 gene expression (Ono et al 2009a). Bioinformatics assessment suggests that C/EBP or CREB binds to the SNP -1748G>A region, OCT-1 binds to the SNP -1565T>C region and the SNP -1045A>G region, and GATA, MZF, and SP1 bind to the SNP -172G>T region (Ono et al 2009b). …”

Section: The Mu Opioid Receptor Gene (Oprm1)mentioning

confidence: 99%

The genetics of the opioid system and specific drug addictions

2012

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Addiction to drugs is a chronic, relapsing brain disease that has major medical, social, and economic complications. It has been established that genetic factors contribute to the vulnerability to develop drug addiction and to the effectiveness of its treatment. Identification of these factors may increase our understanding of the disorders, help in the development of new treatments and advance personalized medicine. In this review we will describe the genetics of the major genes of the opioid system (opioid receptors and their endogenous ligands) in connection to addiction to opioids, cocaine, alcohol and methamphetamines. Particular emphasis is given to association and functional studies of specific variants. We will provide information on the sample populations and the size of each study, as well as a list of the variants implicated in association with addiction-related phenotypes, and with the effectiveness of pharmacotherapy for addiction.

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“…These figures are considerably higher in Asians, with a frequency of 47% reported from Japan [94][95][96] (Table 3). This base exchange has been shown to decrease opioid effects in several experimental and clinical settings.…”

Section: Genetic Variants Influencing Pharmacodynamicsmentioning

confidence: 95%

Personalized Therapy in Pain Management: Where Do We Stand?

Stamer¹,

Zhang

Stüber

2010

Pharmacogenomics

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Genomic variations influencing response to pharmacotherapy of pain are currently under investigation. Drug-metabolizing enzymes represent a major target of ongoing research in order to identify associations between an individual's drug response and genetic profile. Polymorphisms of the cytochrome P450 enzymes (CYP2D6) influence metabolism of codeine, tramadol, hydrocodone, oxycodone and tricyclic antidepressants. Blood concentrations of some NSAIDs depend on CYP2C9 and/or CYP2C8 activity. Genomic variants of these genes associate well with NSAIDs' side effect profile. Other candidate genes, such as those encoding (opioid) receptors, transporters and other molecules important for pharmacotherapy in pain management, are discussed; however, study results are often equivocal. Besides genetic variants, further variables, for example, age, disease, comorbidity, concomitant medication, organ function as well as patients' compliance, may have an impact on pharmacotherapy and need to be addressed when pain therapists prescribe medication. Although pharmacogenetics as a diagnostic tool has the potential to improve patient therapy, well-designed studies are needed to demonstrate superiority to conventional dosing regimes.

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Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of .MU.-Opioid Receptor Gene in Japanese Population

Cited by 7 publications

References 21 publications

The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

The genetics of the opioid system and specific drug addictions

Personalized Therapy in Pain Management: Where Do We Stand?

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