Novel lignin nanoparticles for oral drug delivery

Alqahtani, Mohammed S.; Alqahtani, Ali S.; Al-Thabit, Abdullah; Roni, Monzurul Amin; Syed, Rabbani

doi:10.1039/c9tb00594c

Cited by 120 publications

(74 citation statements)

References 68 publications

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“…Presence of lignin improved potential loading capacity of LNDNG, resulting in more amount of CUR to be absorbed. There is similar reports on the excellent properties of lignin to absorb hydrophobic drugs 50 . Hydrophobic nature of both materials (lignin and CUR) act as pivotal mechanism to absorb CUR on the lignin macromolecule 51 , 52 .…”

Section: Resultssupporting

confidence: 61%

“…Hydrophobic nature of both materials (lignin and CUR) act as pivotal mechanism to absorb CUR on the lignin macromolecule 51 , 52 . A case study on oral delivery of CUR via lignin nanoparticles has shown high affinity of these nanoparticles to entrap CUR molecules and record effective rate of EE 50 . Hyperbranched nature of the lignin make it as a proper candidate to absorb and carry hydrophobic and hydrophilic drugs 53 .…”

Section: Resultsmentioning

confidence: 99%

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Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Dinari

Abdollahi

Majid

2021

Sci Rep

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The story of human dreams about curing all diseases, disorders and lesions is as old as human history. In the frontier of medical science, nanomedicine is trying to solve the problem. In this study, inspired by nanotechnology and using “grafting from” approach, a novel lignin-based nanogel was synthesized using atom transfer radical polymerization (ATRP) method. N-isopropylacrylamide (NIPAM) and N,N-dimethylaminoethylmethacrylate (DMAEMA) comonomers were graft copolymerized from fully brominated lignin as ATRP macroinitiator to synthesize lignin-g-P(NIPAM-co-DMAEMA) nanogel (LNDNG). By controlling the initial comonomer compositions and ATRP conditions, four LNDNG systems with different lower critical solution temperatures (LCSTs) of 32, 34, 37 and 42 °C were prepared. The LNDNGs were evaluated by GPC, FT-IR, 1H NMR, UV–Vis, DLS, SEM and TEM analyses. The prepared nanogels exhibited an average diameter of 150 nm with dual temperature and pH responsiveness. Curcumin (CUR) loading capacity and encapsulation efficiency of the LNDNGs were 49.69% and 92.62% on average, respectively. The cumulative release amount of loaded CUR was observed to be 65.36% after 72 h. The new lignin-based NGs proposed in the present work seems to be a promising, safe and comparable system in a near future.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Dinari

Abdollahi

Majid

2021

Sci Rep

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“…Avoiding premature drug release from drug delivery systems is important to reduce drug toxicity [48]. Nanocarriers play a critical role in the development of formulations as they increase stability [49]. In this study, to evaluate the stability of PLCispt, the cytotoxicity effects of PLCispt were assessed two months after its synthesis and compared to the results from the production day.…”

Section: Stability Studymentioning

confidence: 99%

Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

Ghaferi

Asadollahzadeh

Akbarzadeh

et al. 2020

IJMS

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This study aims to evaluate the potency of cisplatin (Cispt)-loaded liposome (LCispt) and PEGylated liposome (PLCispt) as therapeutic nanoformulations in the treatment of bladder cancer (BC). Cispt was loaded into liposomes using reverse-phase evaporation method, and the formulations were characterized using dynamic light scattering, scanning electron microscopy, dialysis membrane, and Fourier-transform infrared spectroscopy (FTIR) methods. The results showed that the particles were formed in spherical monodispersed shapes with a nanoscale size (221–274 nm) and controlled drug release profile. The cytotoxicity effects of LCispt and PLCispt were assessed in an in vitro environment, and the results demonstrated that PLCispt caused a 2.4- and 1.9-fold increase in the cytotoxicity effects of Cispt after 24 and 48 h, respectively. The therapeutic and toxicity effects of the formulations were also assessed on BC-bearing rats. The results showed that PLCispt caused a 4.8-fold increase in the drug efficacy (tumor volume of 11 ± 0.5 and 2.3 ± 0.1 mm3 in Cispt and PLCispt receiver rats, respectively) and a 3.3-fold decrease in the toxicity effects of the drug (bodyweight gains of 3% and 10% in Cispt and PLCispt receiver rats, respectively). The results of toxicity were also confirmed by histopathological studies. Overall, this study suggests that the PEGylation of LCispt is a promising approach to achieve a nanoformulation with enhanced anticancer effects and reduced toxicity compared to Cispt for the treatment of BC.

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“…Nanocomposites often perform better than traditional composites because of the higher specific surface area of the fillers [ 31 ]. In the last few years, and in view of their potential for improving the physical and mechanical properties of polymer composites, many research efforts have been made to synthesize lignin-based nanoparticles precursors for various nanomaterials manufacturing [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Lignin nanoparticles (LNPs) have shown higher antioxidant property, thermal stability and antibacterial property than their parent materials [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

UV Protective, Antioxidant, Antibacterial and Compostable Polylactic Acid Composites Containing Pristine and Chemically Modified Lignin Nanoparticles

Cavallo

Luzi

et al. 2020

Molecules

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Polylactic acid (PLA) films containing 1 wt % and 3 wt % of lignin nanoparticles (pristine (LNP), chemically modified with citric acid (caLNP) and acetylated (aLNP)) were prepared by extrusion and characterized in terms of their overall performance as food packaging materials. Morphological, mechanical, thermal, UV–Vis barrier, antioxidant and antibacterial properties were assayed; appropriate migration values in food simulants and disintegration in simulated composting conditions were also verified. The results obtained indicated that all lignin nanoparticles succeeded in conferring UV-blocking, antioxidant and antibacterial properties to the PLA films, especially at the higher filler loadings assayed. Chemical modification of the fillers partially reduced the UV protection and the antioxidant properties of the resulting composites, but it induced better nanoparticles dispersion, reduced aggregates size, enhanced ductility and improved aesthetic quality of the films through reduction of the characteristic dark color of lignin. Migration tests and disintegration assays of the nanocomposites in simulated composting conditions indicated that, irrespectively of their formulation, the multifunctional nanocomposite films prepared behaved similarly to neat PLA.

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Novel lignin nanoparticles for oral drug delivery

Abstract: Lignin nanoparticles (LNPs) were prepared with the objective of evaluating their application as a novel oral drug delivery system.

Cited by 120 publications

References 68 publications

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

UV Protective, Antioxidant, Antibacterial and Compostable Polylactic Acid Composites Containing Pristine and Chemically Modified Lignin Nanoparticles

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