“…Methods of tissue destruction include phototherapy, 2 radiofrequency lesioning, 7,40 cryoablation, 53 microwave ablation, 41,52 high-intensity focused ultrasonography, 19,32,55 and laser interstitial thermotherapy. 3,31,49 Mechanisms of tissue destruction include changes in local temperature resulting in coagulation necrosis 18,50 (radiofrequency lesioning, laser interstitial thermotherapy, and high-intensity focused ultrasonography) and cell membrane rupture 18 (cryoablation), generation of free-radicals (phototherapy), and in situ tissue fixation (microwaves). 41 Each of these techniques has selective advantages when used in the brain.…”