Novel laser system and laser irradiation method reduced the risk of carbonization during laser interstitial thermotherapy: Assessed by MR temperature measurement

Aoki, Hideki; Matsumae, Mitsunori; Kaneda, Michihiro; Muro, Isao; Mamata, Yoshiaki; Komiya, Taizo; Tsugu, Atsushi; Tsugane, Ryuichi

doi:10.1002/lsm.1096

Cited by 29 publications

(24 citation statements)

References 26 publications

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“…9b) for m ϭ 128. The estimates of temperature uncertainty with the VCA at single points or along a contour are comparable to single-point uncertainties obtained with optical probes (3,4,22,24,38,41).…”

Section: Discussionsupporting

confidence: 68%

Variation correction algorithm: Analysis of phase suppression and thermal profile fidelity for proton resonance frequency magnetic resonance thermometry at 0.2 T

Barkauskas¹,

Lewin²,

Duerk³

2003

Magnetic Resonance Imaging

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Purpose: To develop and analyze the performance of the variation correction algorithm (VCA), a phase correction technique that mitigates the contribution of background phase variations by combining accurate alignment of echoes, K-space-based phase correction (as opposed to spatial polynomials), and extraction of alias-free phase difference images. Materials and Methods:A series of echo-shifted gradientrecalled echo (GRE) images was processed with K-space alignment and phase corrected with increasing sizes of M ϫ M masks of central K-space coefficients. The extent of background phase variation suppression due to magnet field drift was assessed. Further, a simulated thermal profile was superimposed on the same data in a related experiment. Residual errors in reconstructed simulated thermal profiles were quantitatively characterized to estimate algorithm performance.Results: Using a 3 ϫ 3 K-space mask, the VCA was able to 1) maintain the typical mean backround error in a 35 ϫ 35 pixel region of interest (ROI) at -0.1°C; and 2) reconstruct, relative to the applied thermal profile, a phase-corrected profile that typically contains a 1.7°C underestimation of peak temperature difference and a mean error along the 60°C line of -0.8°C. Conclusion:The results suggest that thermal profiles can be accurately reconstructed at 0.2 T using the VCA, even in the presence of over 1 ppm spatially and temporally dependent field drift over a 1-hour time frame.

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Section: Discussionsupporting

confidence: 68%

Variation correction algorithm: Analysis of phase suppression and thermal profile fidelity for proton resonance frequency magnetic resonance thermometry at 0.2 T

Barkauskas¹,

Lewin²,

Duerk³

2003

Magnetic Resonance Imaging

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“…The ablation was confirmed with histopathological analysis, revealing a submillimeter boundary between the necrotic and normal brain. Reconstructed lesion volumes of 1.655 ± 0.255, 0.599 ± 0.081, and 0.258 ± 0.027 cm 3 were calculated from the postoperative MR images. The accuracy of the computed lesion volumes was limited to the interval between the MR images (2.5-3.0 mm).…”

Section: Discussionmentioning

confidence: 99%

“…Methods of tissue destruction include phototherapy, 2 radiofrequency lesioning, 7,40 cryoablation, 53 microwave ablation, 41,52 high-intensity focused ultrasonography, 19,32,55 and laser interstitial thermotherapy. 3,31,49 Mechanisms of tissue destruction include changes in local temperature resulting in coagulation necrosis 18,50 (radiofrequency lesioning, laser interstitial thermotherapy, and high-intensity focused ultrasonography) and cell membrane rupture 18 (cryoablation), generation of free-radicals (phototherapy), and in situ tissue fixation (microwaves). 41 Each of these techniques has selective advantages when used in the brain.…”

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confidence: 99%

Nonthermal irreversible electroporation for intracranial surgical applications

Ellis

García

Rossmeisl

et al. 2011

JNS

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Object. Nonthermal irreversible electroporation (NTIRE) is a novel, minimally invasive technique to treat cancer, which is unique because of its nonthermal mechanism of tumor ablation. This paper evaluates the safety of an NTIRE procedure to lesion normal canine brain tissue.Methods. The NTIRE procedure involved placing electrodes into a targeted area of brain in 3 dogs and delivering a series of short and intense electric pulses. The voltages of the pulses applied were varied between dogs. Another dog was used as a sham control. One additional dog was treated at an extreme voltage to determine the upper safety limits of the procedure. Ultrasonography was used at the time of the procedure to determine if the lesions could be visualized intraoperatively. The volumes of ablated tissue were then estimated on postprocedure MR imaging. Histological brain sections were then analyzed to evaluate the lesions produced.Results. The animals tolerated the procedure with no apparent complications except for the animal that was treated at the upper voltage limit. The lesion volume appeared to decrease with decreasing voltage of applied pulses. Histological examination revealed cell death within the treated volume with a submillimeter transition zone between necrotic and normal brain.Conclusions. The authors' results reveal that NTIRE at selected voltages can be safely administered in normal canine brain and that the volume of ablated tissue correlates with the voltage of the applied pulses. This preliminary study is the first step toward using NTIRE as a brain cancer treatment.

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“…Laser interstitial thermal therapy (LITT) is a particularly promising technique since small and flexible applicators are readily available, and the means of heating may be controlled to some extent by selection of an appropriate source wavelength and/or applicator [1,2]. However, for effective LITT treatment of focal malignant tumors, accurate prediction of achieved thermal damage is required.…”

Section: Introductionmentioning

confidence: 99%

“…In order to minimize the risk of these effects, it is necessary to control the tissue temperature not only at the boundaries of the desired lesion but also near the applicator as well. While use of laser applicators with diffusing elements has been found to decrease the incidence of char and vaporization [2], smaller diameter applicators, which are desirable because of increased flexibility and reduced insertion trauma, exhibit concomitantly higher power densities at the fiber surface and may therefore lead to deleterious effects if temperature is not properly controlled.…”

Section: Introductionmentioning

confidence: 99%

MR thermometry‐based feedback control of laser interstitial thermal therapy at 980 nm

et al. 2004

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Novel laser system and laser irradiation method reduced the risk of carbonization during laser interstitial thermotherapy: Assessed by MR temperature measurement

Abstract: The use of a diffuse-projection fiber system which intermittently transmits a reduced intensity laser beam is an effective tool to regulate temperature during LITT using MR temperature measurement.

Cited by 29 publications

References 26 publications

Variation correction algorithm: Analysis of phase suppression and thermal profile fidelity for proton resonance frequency magnetic resonance thermometry at 0.2 T

Variation correction algorithm: Analysis of phase suppression and thermal profile fidelity for proton resonance frequency magnetic resonance thermometry at 0.2 T

Nonthermal irreversible electroporation for intracranial surgical applications

MR thermometry‐based feedback control of laser interstitial thermal therapy at 980 nm

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