Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents

“…These complexes show oxidase biometric catalytic activity, anticancer and antimicrobial activities [6][7][8][9][10][11]. The study of Schiff bases and their complexes has become a focal point of interest for chemists in recent years, not only for their several structural features, but due to their potential application in various fields [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectroscopic Investigations of Schiff Bases Transition Metal Complexes of Copper(II), Cobalt(II) and Nickel(II)

Rai¹,

Kumari²,

Rai³

2017

Asian J. Chem.

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This work presents an experimental and theoretical study on complexes of copper(II), cobalt(II) and nickel(II) with Schiff base ligand 3-propyl-(N-o-toluidine)quinazoline semicarbazone (PTQS). The spectroscopic properties of the complexes have been investigated by IR and electronic spectra. The molecular geometry of the complexes have been proposed on the basis of elemental analyses, molar mass and magnetic susceptibility. It is suggested that the ligand PTQS acts in a bidentate manner and coordination proposes with azomethine N and carbonyl oxygen atom of semicarbazone moiety. The remaining coordination sites are occupied by negative ions such as Cl − . The geometry of complexes was assigned to be octahedral.

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“…The trivial name for the title five-membered fully unsaturated heterocycles as "isoxazole" was originally proposed by Hantszch as it was the isomer "oxazole" discovered first. The trivial name follows the Hantszch Widman system of nomenclature: The prefix "iso" represents isomer, "oxa" represents the oxygen atom, "aza" represents the nitrogen atom, and the suffix "ole" denotes the ring size as five-membered; altogether the derived name is "isoxazole" [2][3]. This name has been accepted in IUPAC and has been used in chemical abstracts.…”

Section: Introductionmentioning

confidence: 99%

Isoxazole – A Potent Pharmacophore

Chikkula¹,

Raja

2017

Int J Pharm Pharm Sci

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Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib. Furoxan, a nitric oxide donor is containing isoxazolyl group and found in many β-lactamase resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. The synthetic androgenic steroid danazol also has an isoxazole ring. The substituted isoxazoles are well developed in literature to possess significant biological activities. The disubstituted and trisubstituted isoxazoles have been reported to exhibit broad range of biological activities such as antimicrobial activity, analgesic activity, anti-inflammatory activity, antioxidant activity, anticancer activity, CNS (central nervous system) activity, antitubercular activity and miscellaneous activities like GABA (γ-amino butyric acid) agonistic activity, inhibitory activity, antihypertensive activity, and glutamate transporter activity. The present review summarizes up to date information of various biological activities of isoxazole analogs.

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Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents

Cited by 45 publications

References 49 publications

A copper(II) complex with pyridine-2,6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA

A copper(II) complex with pyridine-2,6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA

Synthesis and Spectroscopic Investigations of Schiff Bases Transition Metal Complexes of Copper(II), Cobalt(II) and Nickel(II)

Isoxazole – A Potent Pharmacophore

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