1998
DOI: 10.1093/hmg/7.13.2121
|View full text |Cite
|
Sign up to set email alerts
|

Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis

Abstract: The fragile X syndrome results from transcriptional silencing of the FMR1 gene and the absence of its encoded FMRP protein. Two autosomal homologues of the FMR1 gene, FXR1 and FXR2, have been identified and the overall structures of the corresponding proteins are very similar to that of FMRP. Using antibodies raised against FXR1P, we observed that two major protein isoforms of relative MW of 78 and 70 kDa are expressed in different mammalian cell lines and in the majority of mouse tissues. In mammalian cells g… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

11
167
0
1

Year Published

2000
2000
2016
2016

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 107 publications
(179 citation statements)
references
References 27 publications
11
167
0
1
Order By: Relevance
“…5,6,16,[19][20][21][22]24 Our previous data demonstrated a role for an isoform of FXR1 in quiescent (extended > 24 h serum-starved) cells, in upregulating translation (independent of RNA level changes) of a critical cytokine, TNFa 17 that can promote monocyte functions, signaling and differentiation. 26,[28][29][30][31] In early (24 h) serumstarved THP1 acute monocytic leukemic cells, our data revealed altered gene expression mechanisms 33 that are distinct from those in quiescent (extended > 24 h serum-starved) cells.…”
Section: Discussionmentioning
confidence: 98%
See 2 more Smart Citations
“…5,6,16,[19][20][21][22]24 Our previous data demonstrated a role for an isoform of FXR1 in quiescent (extended > 24 h serum-starved) cells, in upregulating translation (independent of RNA level changes) of a critical cytokine, TNFa 17 that can promote monocyte functions, signaling and differentiation. 26,[28][29][30][31] In early (24 h) serumstarved THP1 acute monocytic leukemic cells, our data revealed altered gene expression mechanisms 33 that are distinct from those in quiescent (extended > 24 h serum-starved) cells.…”
Section: Discussionmentioning
confidence: 98%
“…FXR1 depletion decreases the ability of monocytes to induce cell migration of neighboring cells FXR1 affects differentiation 5,[19][20][21] and macrophage physiology. 16 Moreover, FXR1 depletion resulted in altered expression of TNFa 23 and other cytokine and chemokine mRNAs 16 such as IL1b and CCL2 (Figs.…”
Section: Il1b Mrna and Protein Levels Are Decreased Upon Fxr1 Depletionmentioning
confidence: 99%
See 1 more Smart Citation
“…Given the well-documented high expression of FMRP in testis and brain (Devys et al 1993, Tamanini et al 1997, Bakker et al 2000, and the lack of FMRP expression in skeletal muscle (Devys et al 1993, Khandjian et al 1998, Bakker et al 2000, these tissues …”
Section: Fmrp Expression Increases As the Follicle Growsmentioning
confidence: 99%
“…La répartition tissulaire et les degrés d'expression de FXR1P suivent ceux de O v a i r e R e i n I n t e s t i n g r ê l e C ô l o n R a t e U t é r u s E s t o m a c P o u m o n F o i e P e a u V e s s i e C oe u r P é r i t o i n e M u s c l e A B FMRP. Les muscles striés cardiaque et squelettiques constituent une exception, puisque seule FXR1P est exprimée sous une forme longue particulière de 82-84 kDa [8]. Les souris Fxr1 -/-meurent quelques minutes après leur naissance, vraisemblablement à cause d'un développement anormal des muscles cardiaque et respiratoires [9].…”
Section: Fragile Comme Un Xunclassified