Novel iron phenanthroline-based photosensitizers for antimicrobial PDT: synthesis, DNA binding and photo-induced DNA cleavage activity

New 4-hydroxy-N-(2-hydroxyethyl)butanamides: Structure and acidity

“…Suitable crystals of 3(±) for X-ray diffraction analyses were obtained from THF (1.7 g, 90%), mp 66À68°C. NMR (DMSO-d 6 …”

“…NMR (DMSO-d 6 (30 mL). Compounds 2(±) or 2(5S,6R) were obtained as colourless solids in 92% (3.6 g).…”

“…Isomers were not distinguished by NMR. NMR (DMSO-d 6 (7) Compound 7 was prepared following the general procedure from (1R,2S)-2-amino-1-phenyl-2-methylethanol (2.0 g, 13.2 mmol) and (±)-a-methyl-c-butyrolactone (1.9 mL, 13.2 mmol) in toluene (30 mL). Colourless solids of a mixture of 7a and 7b were obtained (2.66 g, 80%).…”

“…The design of new metal complexes based on amides ligands derived from unnatural aminoacids is an active research field [3]. The complexes of metal ions and peptides have application as chemosensors [4,5] and as binding and photocleavage of DNA [6] between many other applications. On the other side, optically active ligands for metal ions are widely used in laboratory and industrial transformations, an example of their importance is the series of papers reporting asymmetric catalysing agents for transformations in organic synthesis [7].…”

Spectro-electrochemical assessments of DNA/BSA interactions, cytotoxicity, radical scavenging and pharmacological implications of biosensitive and biologically active morpholine-based metal(ii) complexes: a combined experimental and computational investigation

“…Some examples of classical intercalators include ethidium bromide, actinomycin, adriamycin, anthracyclines, doxorubicin, mitoxantrone, daunorubicin, quinacrine, proavin and propidium, etc. 40 The necessary information on the binding constants and the corresponding free energy, entropy, enthalpy changes on complex-DNA adduct formation can be obtained from thermal denaturation studies. Here, the observed melting temperature of DNA alone was 64 AE 2 C under the same set of experimental conditions, while the observed melting temperature of DNAcompound adducts were in the following order 78 C (1) > 75 C (2) > 74 C (5) > 73 C (4) > 71 C (3) > 68 C (HL) and the change of melting temperature (DT m C) was 14 (1) > 11 (2) > 10 (5) > 9…”