Novel iron(III) complexes based on 2-hydrazinylpyrimidine derivative: Synthesis, characterization and preliminary evaluation of antitumor activity

Yuan, Juan; Yang, Heying; Li, Kai-Hao; Song, Junying; Lan, Hairong; Kou, Hui‐Zhong

doi:10.1016/j.molstruc.2021.130417

Cited by 2 publications

(3 citation statements)

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“…In our previous work, a series of pyrimidine hydrazone derivatives with good antitumor activity have been successfully designed and synthesized. [23][24][25] Fe(III), Ni (II), Co(II) and Zn(II) mononuclear complexes based on monohydrazone derivatives mentioned above were also synthesized, characterized and evaluated. 24,25 It was found that Zn(II) complexes showed better antitumor activity than others.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25] Fe(III), Ni (II), Co(II) and Zn(II) mononuclear complexes based on monohydrazone derivatives mentioned above were also synthesized, characterized and evaluated. 24,25 It was found that Zn(II) complexes showed better antitumor activity than others. 24 Herein, encouraged by the antitumor properties of Zn(II) complexes, tetranuclear grid-like Zn(II) complexes 1-3 based on dihydrazone derivatives H 2 L 1 -H 2 L 3 (Chart 1) were synthesized, characterized and evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…23–25 Fe( iii ), Ni( ii ), Co( ii ) and Zn( ii ) mononuclear complexes based on monohydrazone derivatives mentioned above were also synthesized, characterized and evaluated. 24,25 It was found that Zn( ii ) complexes showed better antitumor activity than others. 24…”

Section: Introductionmentioning

confidence: 99%

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Novel tetranuclear grid-like Zn(ii) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents

Yuan,

Lan,

Xing

et al. 2024

Dalton Trans.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel tetranuclear grid-like Zn(ii) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents

Yuan,

Lan,

Xing

et al. 2024

Dalton Trans.

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Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy

Liu

Huang

et al. 2023

Adv Healthcare Materials

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Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main pathways regulating ferroptosis. Simultaneously, multiple pathways are also involved in the ferroptosis regulation. Ferroptosis is an intense area of the current study. With the improvement of the regulatory mechanisms that underlie ferroptosis, a variety of drugs associated with ferroptosis have been discovered and developed for cancer therapy. Among them, traditional drugs were developed initially. Small molecule compounds that regulate ferroptosis signaling pathway and iron complexes that promote the Fenton reaction have become important drugs for inducing ferroptosis. In recent years, the emerging development of nanotechnology has promoted the research of ferroptosis nanodrugs. Iron‐based nanomaterials are extensively tested as ferroptosis‐inducing agents. Furthermore, nanoscale drug delivery systems offer a suitable scaffold for traditional drug therapies. Traditional drugs and nanodrugs are complementary, each with their own strengths and limitations. This review describes the latest studies on the regulation of ferroptosis in tumor cells and focuses on the entanglement between traditional drugs and nanodrugs. To conclude, the challenges and perspectives in this field are put forward.

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Novel iron(III) complexes based on 2-hydrazinylpyrimidine derivative: Synthesis, characterization and preliminary evaluation of antitumor activity

Cited by 2 publications

References 35 publications

Novel tetranuclear grid-like Zn(ii) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents

Novel tetranuclear grid-like Zn(ii) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents

Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy

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