Novel insights on the role of CD8+ T cells and cytotoxic responses during<i>Helicobacter pylori</i>infection

Kronsteiner, Barbara; Bassaganya‐Riera, Josep; Philipson, Noah; Hontecillas, Raquel

doi:10.4161/gmic.28899

Cited by 24 publications

(17 citation statements)

References 51 publications

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“…13 The mechanism of cellular immunity induced by CD8+ T cell in H. pylori is unknown; however, Kronsteine has suggested that increased frequency of CD8+ T cells might be a consequence of intracellular antigen processing and probably antigen cross-presentation. 13 The mechanism of cellular immunity induced by CD8+ T cell in H. pylori is unknown; however, Kronsteine has suggested that increased frequency of CD8+ T cells might be a consequence of intracellular antigen processing and probably antigen cross-presentation.…”

Section: In Vitro Cytokine Production By Pbmcs Stimulated With H Pmentioning

confidence: 99%

“…9 Th22 cells exert pro-inflammatory effects through a synergistic action with proinflammatory mediators such as TNFα and IL-17A. 13 Therefore, our study design evaluates the effects of T-cell subsets on immune responses to H. pylori infection. 11,12 In recent years, data from human clinical studies have emphasized the potential involvement of other T-cell subsets, including the CD8+ cytotoxic T lymphocytes, in the context of immune responses to H. pylori.…”

Section: Introductionmentioning

confidence: 99%

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The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori‐associated gastric diseases

et al. 2016

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Section: In Vitro Cytokine Production By Pbmcs Stimulated With H Pmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori‐associated gastric diseases

et al. 2016

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“…Global sensitivity analysis has revealed that epithelial cells and macrophages have the highest influence in the mucosal immune response to H. pylori. The prediction of the impact of epithelial cells support the model itself, since most of H. pylori is found in contact with epithelium, 24,146,147 and the epithelial cell has been implicated in the initiation of innate responses (as discussed above).…”

mentioning

confidence: 53%

Systems-wide analyses of mucosal immune responses toHelicobacter pyloriat the interface between pathogenicity and symbiosis

Kronsteiner

Bassaganya‐Riera

Philipson³

et al. 2016

Gut Microbes

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Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5-15% develop gastritis or gastric malignancies. Immune responses to H. pylori are characterized by mixed T helper cell, cytotoxic T cell and NK cell responses. The presence of Tregs is essential for the control of gastritis and together with regulatory CX3CR1C mononuclear phagocytes and immune-evasion strategies they enable life-long persistence of H. pylori. This H. pylori-induced regulatory environment might contribute to its cross-protective effect in inflammatory bowel disease and obesity. Here we review host-microbe interactions, the development of pro-and anti-inflammatory immune responses and how the latter contribute to H. pylori's role as beneficial member of the gut microbiota. Furthermore, we present the integration of existing and new data into a computational/mathematical model and its use for the investigation of immunological mechanisms underlying initiation, progression and outcomes of H. pylori infection.

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“…It was previously shown that Helicobacter infection induces CD8 + T cell responses in pigs (38), which suggests that the CD8 + induction in Dvl1 −/− mice was due to increased opportunistic bacterial pathogen enrichment caused by abnormal Paneth cell function (Figure 4). However, the fact that WT mice reconstituted with Dvl1 -mutant bone marrow displayed an increased number of CD8 + T cells, but with normal Paneth cells, suggests that loss of Dvl1 has an intrinsic effect on the hematopoietic compartment.…”

Section: Discussionmentioning

confidence: 81%

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis

Belinson¹,

Savage²,

Fadrosh³

et al. 2016

JCI Insight

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Homeostasis of the gastrointestinal (GI) tract is controlled by complex interactions between epithelial and immune cells and the resident microbiota. Here, we studied the role of Wnt signaling in GI homeostasis using Disheveled 1 knockout (Dvl1−/−) mice, which display an increase in whole gut transit time. This phenotype is associated with a reduction and mislocalization of Paneth cells and an increase in CD8+ T cells in the lamina propria. Bone marrow chimera experiments demonstrated that GI dysfunction requires abnormalities in both epithelial and immune cells. Dvl1−/− mice exhibit a significantly distinct GI microbiota, and manipulation of the gut microbiota in mutant mice rescued the GI transit abnormality without correcting the Paneth and CD8+ T cell abnormalities. Moreover, manipulation of the gut microbiota in wild-type mice induced a GI transit abnormality akin to that seen in Dvl1−/− mice. Together, these data indicate that microbiota manipulation can overcome host dysfunction to correct GI transit abnormalities. Our findings illustrate a mechanism by which the epithelium and immune system coregulate gut microbiota composition to promote normal GI function.

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Novel insights on the role of CD8+ T cells and cytotoxic responses duringHelicobacter pyloriinfection

Cited by 24 publications

References 51 publications

The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori‐associated gastric diseases

The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori‐associated gastric diseases

Systems-wide analyses of mucosal immune responses toHelicobacter pyloriat the interface between pathogenicity and symbiosis

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis

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