Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer
Namita Chutani,
Sandhya Ragula,
Khajamohiddin Syed
et al.
Abstract:A newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain. MORC2 is highly expressed in a variety of human cancers. It controls diverse signaling pathways essential for cancer development through its target genes and interacting partners. MORC2 promotes cancer cells’ growth, invasion, and migration by regulating the expression of genes involved in these processes. M… Show more
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