Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X

Brunner, Magdalena A. T.; Jagannathan, Vidhya; Waluk, Dominik P.; Roosje, Petra; Линек, Моника; Panakova, Lucia; Leeb, Tosso; Wiener, Dominique J; Welle, Monika Maria

doi:10.1371/journal.pone.0186469

Cited by 26 publications

(54 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,7 Although novel mechanisms for dysregulation of sex hormone metabolism in Pomeranians with Alopecia X have been proposed, they remain unproven. 18 When compared to normal-coated schipperkes, affected animals in this study had changes similar to those described previously in Pomeranians 19 and other plush-coated breeds. 20 Although the majority of noninflammatory alopecic conditions cannot be diagnosed definitely with histopathology alone, 20 there are multiple features previously described and confirmed in the affected schipperkes which support a similarity to Alopecia X.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Description and characterization of a hair coat disorder in schipperkes

May

Frank

Sula

2018

Veterinary Dermatology

View full text Add to dashboard Cite

Background Schipperkes develop bilaterally symmetrical alopecia preceded by lightening of the hair coat not associated with systemic clinical signs. The alopecia is presumptively diagnosed as Alopecia X but has never been investigated. Hypothesis/Objectives The purpose of this study was to describe clinical features, histopathological and laboratory abnormalities associated with symmetrical, noninflammatory alopecia in schipperkes. Animals Three healthy and eight affected schipperkes. Methods and materials Complete blood count (CBC), serum chemistry panel, urinalysis (UA), urine cortisol: creatinine ratio (UCCR), total thyroxine (T4), free thyroxine by equilibrium dialysis (fT4ed), thyroid stimulating hormone (TSH) and pre‐ and post‐stimulation cortisol with sex hormone analyses were performed for all dogs. A minimum of two skin biopsy sites were sampled for histopathological evaluation. Results The CBC, serum chemistry panel, UA, T4, fT4ed, TSH and post‐ACTH cortisol concentrations were normal for all dogs. Androstenedione concentrations were increased for all dogs; two of three healthy and five of eight affected dogs had increased post‐ACTH androstenedione concentrations. Estradiol concentrations were increased for all healthy and four of eight affected dogs, with post‐ACTH estradiol concentrations increased for all healthy and five of eight affected dogs. Progesterone concentrations were increased for two of three healthy and four of eight affected dogs. Post‐ACTH progesterone concentrations were increased for one of three healthy and four of eight affected dogs. For one of three healthy and two of eight affected dogs, 17‐hydroxyprogesterone concentrations were increased; post‐ACTH 17‐hydroxyprogesterone concentrations were increased in three of eight affected dogs only. Histopathology results from affected dogs were consistent with hair cycle arrest. Conclusions and clinical importance This disorder resembles Alopecia X clinically and histologically.

show abstract

Section: Discussionsupporting

confidence: 82%

“…They also are similar to those for other breeds that develop Alopecia X, including the Pomeranian, keeshond, Siberian husky and miniature poodle . Although novel mechanisms for dysregulation of sex hormone metabolism in Pomeranians with Alopecia X have been proposed, they remain unproven …”

Section: Discussionsupporting

confidence: 57%

Description and characterization of a hair coat disorder in schipperkes

May

Frank

Sula

2018

Veterinary Dermatology

View full text Add to dashboard Cite

show abstract

“…Furthermore, a recent GWAS identified a missense mutation in the xenobiotic and steroid hormone metabolising enzyme, CYP1B1, linked with pathogenesis of FFA . CYP1B1, which has been associated with alopecia X in Pomeranian dogs, plays a role in the oxidative metabolism of estradiol and estrone, but may also metabolise xenobiotics such as the oral contraceptive . Although this could again point to a role for steroid hormone metabolism in development of hair disorders such as FFA, it does not provide direct evidence of a role for intrafollicular steroidogenesis.…”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 99%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

show abstract

“…CUX1 stimulates TCF/βcatenin transcriptional activity [19]. JAG1 and CDH3, as target genes of the WNT signaling pathway, are key factors in the transition of hair from early anagen to late anagen [20]. HF differentiation is characterized by development of all the compartments of the HF, and different signal molecules play specific roles in this process.…”

Section: Signaling and Transcription Pathways During The Hair Cyclementioning

confidence: 99%

The seasonal development dynamics of the yak hair cycle transcriptome

Bao

Luo

Liu

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Mammalian hair play an important role in mammals' ability to adapt to changing climatic environments. The seasonal circulation of yak hair helps them adapt to high altitude but the regulation mechanisms of the proliferation and differentiation of hair follicle (HF) cells during development are still unknown. Here, using time series data for whole genome expression profiles and hormone contents, we systematically analyzed the mechanism regulating the periodic expression of hair development in the yak and reviewed how different combinations of genetic pathways regulate HF development and cycling. Results: This study used high-throughput RNA sequencing to provide a detailed description of global gene expression in 15 samples from five developmental time points during the yak hair cycle. A total of 11,666 genes were found to be involved in the hair cycle. According to clustering analysis and the morphological features we observed, we found that these 15 samples could be significantly grouped into three phases, which represent different developmental periods in the hair cycle. A total of 2,316 genes were identified in these three consecutive developmental periods and their expression patterns could be divided into 9 clusters; GO annotation and KEGG pathway enrichment were performed on these differentially expressed genes (DEGs), showing that the three periods have distinctive functions in the seasonal hair cycle. The regulatory network of related signaling factors highlighted the interaction and dynamic expression of key DEGs during the seasonal hair cycle. Through co-expression analysis, we revealed a number of modular hub genes highly associated with hormones that may play unique roles in hormonal regulation of events associated with the hair cycle. Conclusions: Our results revealed the molecular mechanisms and developmental regulatory networks of the seasonal hair cycle in the yak and filled a gap in the current research field. The findings will be valuable in further understanding the alpine adaptation mechanism in the yak, which is important in order to make full use of yak hair resources and promote the economic development of pastoral plateau areas. Keywords: Hair cycle, Seasonal development, Transcriptome, Yak

show abstract

Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X

Cited by 26 publications

References 74 publications

Description and characterization of a hair coat disorder in schipperkes

Description and characterization of a hair coat disorder in schipperkes

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

The seasonal development dynamics of the yak hair cycle transcriptome

Contact Info

Product

Resources

About