Novel Insights into Psychosis and Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes
Adonis Sfera,
Hassan Imran,
Dan O. Sfera
et al.
Abstract:For the past 70 years, the dopamine hypothesis has been the key working model in schizophrenia. This has contributed to the development of numerous inhibitors of dopaminergic signaling and antipsychotic drugs, which led to rapid symptom resolution but only marginal outcome improvement. Over the past decades, there has been limited research on the quantifiable pathological changes in schizophrenia, including premature cellular/neuronal senescence, brain volume loss, the attenuation of gamma oscillations in elec… Show more
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