Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts
Brian Gural,
Logan Kirkland,
Abbey Hockett
et al.
Abstract:BackgroundRecent advances in single cell sequencing have led to an increased focus on the role of cell-type composition in phenotypic presentation and disease progression. Cell-type composition research in the heart is challenging due to large, frequently multinucleated cardiomyocytes that preclude most single cell approaches from obtaining accurate measurements of cell composition. Ourin silicostudies reveal that ignoring cell type composition when calculating differentially expressed genes (DEGs) can have si… Show more
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