2021
DOI: 10.1101/2021.03.30.437775
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Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons

Abstract: Pathophysiological damages and loss of function of dopamine neurons precedes their demise and contributes to the early phases of Parkinson's disease. The presence of aberrant intercellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of Parkinson's disease. We employed multiple complementary approaches in molecular biology, electrophysiology, and live-cell imaging to investigate how excessive α-synuclein levels alters multiple c… Show more

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Cited by 3 publications
(1 citation statement)
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References 143 publications
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“…Since these alterations of neuronal function take place before neuronal death, they represent an interesting target for monitoring the early stages of neurodegeneration. Other effects in models overexpressing mutant α-syn include an impaired activity of type-A potassium channels, and, more recently, disruption of Ca 2+ dynamics and reduced D 2 -autoreceptor inhibition (Subramaniam et al, 2014;Dagra et al, 2021;Lin et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Since these alterations of neuronal function take place before neuronal death, they represent an interesting target for monitoring the early stages of neurodegeneration. Other effects in models overexpressing mutant α-syn include an impaired activity of type-A potassium channels, and, more recently, disruption of Ca 2+ dynamics and reduced D 2 -autoreceptor inhibition (Subramaniam et al, 2014;Dagra et al, 2021;Lin et al, 2021).…”
Section: Discussionmentioning
confidence: 99%